N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate
CAS No.:1354721-74-6
Molecular Formula:C₂HF₃O₂*C₃₂H₃₀ClF₃N₆O₄
Molecular Weight:769.1
Hs Code.:

N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

Synonyms:N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

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Chemical Property of N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

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Technology Process of N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

There total 10 articles about N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 22.0%

: 1354721-87-1
3-(methyl-(2-morpholinoethyl)carbamoyl)benzoyl chloride

: 1354722-17-0
2-amino-5-chloro-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide

: 1354721-74-6
N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

Guidance literature:: 3-(methyl-(2-morpholinoethyl)carbamoyl)benzoyl chloride; 2-amino-5-chloro-N-(1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)benzamide; With pyridine; In dichloromethane; at 0 - 20 ℃; for 1h;

With ammonium hydroxide; In dichloromethane; water; pH=8;

Reference yield:

: 2038-03-1
4-(2-AMINOETHYL)MORPHOLINE

: 1354721-74-6
N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 0 - 25 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 70 °C

3.1: triethylamine / dichloromethane / 0 - 20 °C

4.1: sodium hydroxide; lithium hydroxide monohydrate / tetrahydrofuran / 1 h / 25 °C

4.2: pH 2 - 3

5.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h / 50 °C

6.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

6.2: pH 8

With pyridine; lithium aluminium tetrahydride; oxalyl dichloride; lithium hydroxide monohydrate; triethylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 401-81-0
m-trifluoromethylphenyl iodide

: 1354721-74-6
N-(4-chloro-2-((1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-yl)carbamoyl)phenyl)-N'-methyl-N'-(2-morpholinoethyl)isophthalamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate; L-proline; copper(l) iodide / dimethyl sulfoxide / 85 °C

2.1: hydrogen / palladium on activated charcoal / methanol / 20 °C

3.1: pyridine / 1 h / 20 °C

4.1: zinc; acetic acid / 1 h / 70 °C

4.2: pH 8

5.1: pyridine / dichloromethane / 1 h / 0 - 20 °C

5.2: pH 8

With pyridine; copper(l) iodide; hydrogen; potassium carbonate; acetic acid; L-proline; zinc; palladium on activated charcoal; In methanol; dichloromethane; dimethyl sulfoxide;