(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Name:(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:90282-78-3
Molecular Formula:C₃₅H₄₅N₅O₈
Molecular Weight:663.771
Hs Code.:

(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Synonyms:(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of (S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

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Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of (S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

There total 5 articles about (S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1738-76-7
glycine benzyl ester p-toluenesulfonic acid salt

: 90282-78-3
(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

2: 95 percent / 4 M hydrochloric acid / dioxane

3: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

4: 92 percent / 4 M hydrochloric acid / dioxane

5: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;
DOI:10.1246/bcsj.57.90

Reference yield:

: 7797-34-4
benzylglycylglycinate hydrochloride

: 90282-78-3
(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

2: 92 percent / 4 M hydrochloric acid / dioxane

3: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;
DOI:10.1246/bcsj.57.90

Reference yield:

: 31972-51-7
N-(tert-butoxycarbonyl)glycylglycine benzyl ester

: 90282-78-3
(S)-2-[(S)-2-((S)-1-{[(Benzyloxycarbonylmethyl-carbamoyl)-methyl]-carbamoyl}-2-phenyl-ethylcarbamoyl)-pyrrolidine-1-carbonyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / 4 M hydrochloric acid / dioxane

2: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

3: 92 percent / 4 M hydrochloric acid / dioxane

4: 1) NMM, ECF, 2) NMM / 1) DMF, -5 deg C, 10 min, 2) CHCl₃, ice bath, 1 h; r.t., overnight

With 4-methyl-morpholine; hydrogenchloride; chloroformic acid ethyl ester; In 1,4-dioxane;
DOI:10.1246/bcsj.57.90