31972-51-7Relevant academic research and scientific papers
Glycopeptide derivatives for the preservation and protection of biological materials and microorganisms
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Page/Page column 58-60, (2018/11/06)
The present invention relates to a compound of the following formula (I): in which at least one and only one group chosen among R5, R6 and R7 is a group of the following formula: The present invention relates also to uses
Stereoselective and Site-Specific Allylic Alkylation of Amino Acids and Small Peptides via a Pd/Cu Dual Catalysis
Huo, Xiaohong,He, Rui,Fu, Jingke,Zhang, Jiacheng,Yang, Guoqiang,Zhang, Wanbin
supporting information, p. 9819 - 9822 (2017/08/02)
We report a stereoselective and site-specific allylic alkylation of Schiff base activated amino acids and small peptides via a Pd/Cu dual catalysis. A range of noncoded α,α-dialkyl α-amino acids were easily synthesized in high yields and with excellent enantioselectivities (up to >99% ee). Furthermore, a direct and highly stereoselective synthesis of small peptides with enantiopure α-alkyl or α,α-dialkyl α-amino acids residues incorporated at specific sites was accomplished using this dual catalyst system.
Borinic acid catalysed peptide synthesis
El Dine, Tharwat Mohy,Rouden, Jacques,Blanchet, Jér?me
supporting information, p. 16084 - 16087 (2015/11/10)
The catalytic synthesis of peptides is a major challenge in the modern organic chemistry hindered by the well-established use of stoichiometric coupling reagents. Herein, we describe for the first time that borinic acid is able to catalyse this reaction under mild conditions with an improved activity compared to our recently developed thiophene-based boronic acid. This catalyst is particularly efficient for peptide bond synthesis affording dipeptides in good yields without detectable racemization.
RGD-fatty alcohol-modified docetaxel liposomes improve tumor selectivity in vivo
Li, Yinghuan,Zheng, Xuelian,Sun, Yi,Ren, Zhao,Li, Xuemei,Cui, Guohui
, p. 133 - 141 (2014/05/20)
The tripeptide arginine-glycine-aspartate (RGD) was conjugated with various fatty alcohols to obtain RGDOCnH2n + 1 (n = 8, 10, 12, 14, 16, 18), which were incorporated into the bilayer of docetaxel liposomes to improve their tumor sp
One-pot mechanosynthesis of aromatic amides and dipeptides from carboxylic acids and amines
?trukil, Vjekoslav,Bartolec, Boris,Portada, Tomislav,Dilovi?, Ivica,Halasz, Ivan,Margeti?, Davor
supporting information, p. 12100 - 12102 (2013/01/16)
Environmentally friendly one-pot synthesis of amides, bis-amides and dipeptides by mechanochemical carbodiimide-mediated coupling of carboxylic acids and amines is described; high reaction yields and simple aqueous work-up allow for the clean, practical and fast preparation of a variety of compounds containing the amide bond from readily accessible reagents.
Novel tetrapeptide, RGDF, mediated tumor specific liposomal doxorubicin (DOX) preparations
Du, Huirui,Cui, Chunying,Wang, Lili,Liu, Hu,Cui, Guohui
experimental part, p. 1224 - 1232 (2012/05/04)
Arginine-glycine-aspartate (RGD) has been shown to possess a strong affinity for the integrins overexpressed in tumor cells, especially during tumor invasion, angiogenesis and metasis. Based on work from others, a novel tetrapeptide, arginine-glycine-aspa
Design, synthesis and inhibition activity of novel cyclic peptides against protein tyrosine phosphatase A from Mycobacterium tuberculosis
Chandra, Koushik,Dutta, Debajyoti,Das, Amit K.,Basak, Amit
supporting information; scheme or table, p. 8365 - 8373 (2011/02/25)
Mycobacterium tuberculosis, the causative agent for tuberculosis has employed several signalling molecules to sense the host cellular environment and act accordingly. For example, protein tyrosine phosphatase A (MPtpA) of M. tuberculosis, a signalling pro
Development of supramolecular organo-gel based on tripeptide skeletons
Azuma, Eriko,Kuramochi, Kouji,Tsubaki, Kazunori
body text, p. 680 - 684 (2010/07/15)
Boc-Ser-Val-Gly-OCH2Ph (31) showed high gelation abilities in the aromatic solvents, particularly in toluene. The minimum gelation concentration of 31 in toluene was 10 mg/ml, suggesting that 2500 molecules of toluene were immobilized by each m
Synthesis of chimeric tetrapeptide-linked cholic acid derivatives: Impending synergistic agents
Bavikar, Sudhir N.,Salunke, Deepak B.,Hazra, Braja G.,Pore, Vandana S.,Dodd, Robert H.,Thierry, Josiane,Shirazi, Fazal,Deshpande, Mukund V.,Kadreppa, Sreenath,Chattopadhyay, Samit
supporting information; experimental part, p. 5512 - 5517 (2009/06/18)
Tetrapeptides derived from glycine and β-alanine were hooked at the C-3β position of the modified cholic acid to realize novel linear tetrapeptide-linked cholic acid derivatives. All the synthesized compounds were tested against a wide variety of microorganisms (Gram-negative bacteria, Gram-positive bacteria and fungi) and their cytotoxicity was evaluated against human embryonic kidney (HEK293) and human mammary adenocarcinoma (MCF-7) cell lines. While relatively inactive by themselves, these compounds interact synergistically with antibiotics such as fluconazole and erythromycin to inhibit growth of fungi and bacteria, respectively, at 1-24 μg/mL. The synergistic effect shown by our novel compounds is due to their inherent amphiphilicity. The fractional inhibitory concentrations reported are comparable to those reported for Polymyxin B derivatives.
A templating approach for monodisperse self-assembled organic nanostructures
Bull, Steve R.,Palmer, Liam C.,Fry, Nathaniel J.,Greenfield, Megan A.,Messmore, Benjamin W.,Meade, Thomas J.,Stupp, Samuel I.
, p. 2742 - 2743 (2008/09/20)
The precise structural control is known for self-assembly into closed spherical structures (e.g., micelles), but similar control of open structures is much more challenging. Inspired by natural tobacco mosaic virus, we present the use of a rigid-rod template to control the size of a one-dimensional self-assembly. We believe that this strategy is novel for organic self-assembly and should provide a general approach to controlling size and dimension. Copyright
