2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Base Information

Chemical Name:2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile
CAS No.:1201646-06-1
Molecular Formula:C₂₆H₂₂N₆
Molecular Weight:418.501
Hs Code.:

Synonyms:2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Chemical Property of 2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

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Technology Process of 2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

There total 3 articles about 2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1201646-07-2
tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

: 1201646-06-1
2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate; With hydrogenchloride; water; In methanol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; water; pH=7.5;

Reference yield:

: 1171897-39-4
tert-butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate

: 1201646-06-1
2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

2.1: hydrogenchloride; water / methanol / 2 h / 20 °C

2.2: pH 7.5

With hydrogenchloride; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1201645-84-2
2-(4-(8-bromo-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 1201646-06-1
2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 0.5 h / 120 °C / Microwave irradiation

2.1: hydrogenchloride; water / methanol / 2 h / 20 °C

2.2: pH 7.5

With hydrogenchloride; water; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; water; N,N-dimethyl-formamide;