tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Base Information

Chemical Name:tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate
CAS No.:1201646-07-2
Molecular Formula:C₃₁H₃₀N₆O₂
Molecular Weight:518.618
Hs Code.:

Synonyms:tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

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Chemical Property of tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

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Technology Process of tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

There total 1 articles about tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1171897-39-4
tert-butyl (5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)carbamate

: 1201645-84-2
2-(4-(8-bromo-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

: 1201646-07-2
tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; N,N-dimethyl-formamide; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield: 90.0%

: 1201646-07-2
tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

: 1201646-06-1
2-(4-(8-(5-aminopyridin-3-yl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-1-yl)phenyl)-2-methylpropanenitrile

Guidance literature:: tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate; With hydrogenchloride; water; In methanol; at 20 ℃; for 2h;

With sodium hydrogencarbonate; In methanol; water; pH=7.5;

Reference yield:

: 1201646-07-2
tert-butyl-5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-ylcarbamate

: 1201646-08-3
N-(5-(1-(4-(2-cyanopropan-2-yl)phenyl)-3-methyl-3H-pyrazolo[3,4-c]quinolin-8-yl)pyridin-3-yl)acetamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride; water / methanol / 2 h / 20 °C

1.2: pH 7.5

2.1: pyridine / dichloromethane / 15 h / 20 °C

With pyridine; hydrogenchloride; water; In methanol; dichloromethane;