4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Base Information

Chemical Name:4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol
CAS No.:1262414-06-1
Molecular Formula:C₂₂H₂₅N₃O₃
Molecular Weight:379.459
Hs Code.:

Synonyms:4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Suppliers and Price of 4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Chemical Property:

Boiling Point:576.2±60.0 °C(Predicted)
Density:1.195±0.06 g/cm3(Predicted)

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

There total 11 articles about 4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 1262414-06-1
4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; methanol / water / 4 h / 34 - 70 °C

1.2: 20 °C

2.1: sulfuric acid / methanol / 24 h / Reflux

3.1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

4.1: hydrogenchloride; sodium hydroxide / ethanol; water / 0.5 h / 90 °C

5.1: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 66 h / 5 - 75 °C

With hydrogenchloride; methanol; sulfuric acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; water;

Reference yield:

: 42521-10-8
2-chloro-6-methoxyisonicotinic acid methyl ester

: 1262414-06-1
4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Guidance literature:: Multi-step reaction with 3 steps

1: bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾ / water; tetrahydrofuran / 3 h / 85 °C / Inert atmosphere

2: hydrogenchloride; sodium hydroxide / ethanol; water / 0.5 h / 90 °C

3: dicyclohexyl-carbodiimide; benzotriazol-1-ol / tetrahydrofuran / 66 h / 5 - 75 °C

With hydrogenchloride; benzotriazol-1-ol; dicyclohexyl-carbodiimide; sodium hydroxide; bis[1,2-bis(diphenylphosphino)ferrocene]-palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water;

Reference yield:

: 910635-33-5
3-ethyl-N,4-dihydroxy-5-methylbenzimidamide

: 1122089-67-1
2-cyclopentyl-6-methoxypyridine-4-carboxylic acid

: 1262414-06-1
4-[5-(2-cyclopentyl-6-methoxypyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-ethyl-6-methylphenol

Guidance literature:: 3-ethyl-N,4-dihydroxy-5-methylbenzimidamide; 2-cyclopentyl-6-methoxypyridine-4-carboxylic acid; With benzotriazol-1-ol; In tetrahydrofuran; at 5 ℃;

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 - 75 ℃; for 66h;