3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one

Base Information

• Chemical Name: 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one
• CAS No.: 1637568-91-2
• Molecular Formula: C₁₈H₁₇ClO₅
• Molecular Weight: 348.783
• Mol file: 1637568-91-2.mol

Synonyms:3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one

Chemical Property of 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one

There total 4 articles about 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

6-hydroxy-2,3,4-trimethoxyacetophenone (22248-14-2) + 4-chlorobenzaldehyde (104-88-1) → 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one (1637568-91-2)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1002/cbdv.201400181

Reference yield:

3,4,5-trimethoxyphenol (642-71-7) + p-chlorocinnamoyl chloride (35086-79-4) → 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one (1637568-91-2)

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; for 0.166667h; Reflux;

DOI:10.1248/cpb.c13-00897

Reference yield:

3,4,5-trimethoxyphenol (642-71-7) → 3-(4-chlorophenyl)-1-(6-hydroxy-2,3,4-trimethoxyphenyl)prop-2-en-1-one (1637568-91-2)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / toluene / 2 h / Reflux; Inert atmosphere

2: potassium hydroxide / dimethyl sulfoxide / 20 °C / Inert atmosphere

With boron trifluoride diethyl etherate; potassium hydroxide; In dimethyl sulfoxide; toluene; 2: |Claisen-Schmidt Condensation;

DOI:10.1002/cbdv.201400181

upstream raw materials:

p-chlorocinnamic acid

3,4,5-trimethoxyphenol

p-chlorocinnamoyl chloride

6-hydroxy-2,3,4-trimethoxyacetophenone

Downstream raw materials:

2-(4-chlorophenyl)-5,6,7-trimethoxy-4H-chromen-4-one

C₁₅H₉ClO₅