2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

Base Information

Chemical Name:2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride
CAS No.:78609-69-5
Molecular Formula:C₂₈H₃₆Cl₂N₂O₃*ClH
Molecular Weight:555.972
Hs Code.:

Synonyms:2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

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Chemical Property of 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

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Technology Process of 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

There total 3 articles about 2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78431-89-7
{4-[Bis-(2-hydroxy-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester

: 78609-69-5
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

2: 80 percent / aq. HCl / 1.5 h / Heating

3: 68 percent / 1,3-dicyclohexylcarbodiimide

With hydrogenchloride; thionyl chloride; dicyclohexyl-carbodiimide; In chloroform;
DOI:10.1007/BF00962271

Reference yield:

: 76308-15-1
cis-4-aminocyclohexylacetic acid ethyl ester

: 78609-69-5
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / H₂O

2: 75 percent / SOCl₂ / CHCl₃ / 1 h / 20 °C

3: 80 percent / aq. HCl / 1.5 h / Heating

4: 68 percent / 1,3-dicyclohexylcarbodiimide

With hydrogenchloride; thionyl chloride; dicyclohexyl-carbodiimide; In chloroform; water;
DOI:10.1007/BF00962271

Reference yield:

: 78431-92-2
{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetic acid ethyl ester; hydrochloride

: 78609-69-5
2-(2-{4-[Bis-(2-chloro-ethyl)-amino]-cyclohexyl}-acetylamino)-3-phenyl-propionic acid benzyl ester; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / aq. HCl / 1.5 h / Heating

2: 68 percent / 1,3-dicyclohexylcarbodiimide

With hydrogenchloride; dicyclohexyl-carbodiimide;
DOI:10.1007/BF00962271