2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

Base Information

Chemical Name:2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
CAS No.:137648-18-1
Molecular Formula:C₁₇H₁₅F₂N₅O₄
Molecular Weight:391.334
Hs Code.:

Synonyms:2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

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Technology Process of 2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

There total 3 articles about 2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 134217-14-4
2-fluoro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

: 137648-18-1
2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

Guidance literature:: With sodium hydrogencarbonate; In methanol; for 2.5h; Ambient temperature;
DOI:10.1021/jm00080a029

Reference yield:

: 103885-02-5
9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

: 137648-18-1
2-fluoro-9-(5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) HF, pyridine, tert-butyl nitrite, 2.) aq. NaHCO₃ / 1.) -20 deg C, 3 h, 2.) 20 min

2: 74 percent / NaHCO₃ / methanol / 2.5 h / Ambient temperature

With pyridine; tert.-butylnitrite; hydrogen fluoride; sodium hydrogencarbonate; In methanol;
DOI:10.1021/jm00080a029