9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

Base Information

Chemical Name:9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine
CAS No.:103885-02-5
Molecular Formula:C₁₉H₁₉FN₆O₅
Molecular Weight:430.395
Hs Code.:

Synonyms:9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

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Chemical Property of 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

There total 5 articles about 9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 103885-01-4
2,6-diazido-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

: 103885-02-5
9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethanol; for 5h; under 760 Torr;
DOI:10.1021/jm00161a041

Reference yield:

: 56632-81-6
1,3-di-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-D-arabinofuranosyl bromide

: 103885-02-5
9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 3 steps

1: 4A molecular sieves / 1,2-dichloro-ethane / 16 h / Heating

2: 72 percent / aq. NaN₃ / ethanol / 0.5 h / Heating

3: 80 percent / H₂ / 5percent Pd/C / ethanol / 5 h / 760 Torr

With sodium azide; 4 A molecular sieve; hydrogen; palladium on activated charcoal; In ethanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00161a041

Reference yield:

: 103884-99-7
2,6-dichloro-9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine

: 103885-02-5
9-(3-O-acetyl-5-O-benzoyl-2-deoxy-2-fluoro-β-D-arabinofuranosyl)-9H-purine-2,6-diamine

Guidance literature:: Multi-step reaction with 2 steps

1: 72 percent / aq. NaN₃ / ethanol / 0.5 h / Heating

2: 80 percent / H₂ / 5percent Pd/C / ethanol / 5 h / 760 Torr

With sodium azide; hydrogen; palladium on activated charcoal; In ethanol;
DOI:10.1021/jm00161a041