2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Base Information

• Chemical Name: 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide
• CAS No.: 350603-07-5
• Molecular Formula: C₃₀H₂₈N₄O₃
• Molecular Weight: 492.577
• Mol file: 350603-07-5.mol

Synonyms:2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Chemical Property of 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

There total 3 articles about 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide (350603-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 16 h / 20 °C

2: 91 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; benzene;

DOI:10.1016/S0040-4020(01)00637-8

Reference yield:

2-(N-benzyl-N-prop-2'-ynyl)aminobenzoic acid (267890-09-5) → 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide (350603-07-5)

Guidance literature:

Multi-step reaction with 3 steps

1: SOCl₂; pyridine / benzene / 1.5 h / 55 °C

2: benzene / 16 h / 20 °C

3: 91 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

With pyridine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; triethylamine; In acetonitrile; benzene;

DOI:10.1016/S0040-4020(01)00637-8

Reference yield:

2-(benzyl-prop-2-ynyl-amino)-benzoyl chloride → 2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide (350603-07-5)

Guidance literature:

Multi-step reaction with 2 steps

1: benzene / 16 h / 20 °C

2: 91 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; benzene;

DOI:10.1016/S0040-4020(01)00637-8

upstream raw materials:

p-toluidine

2-(N-benzyl-N-prop-2'-ynyl)aminobenzoic acid

Downstream raw materials:

1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones