1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Base Information

• Chemical Name: 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones
• CAS No.: 350603-15-5
• Molecular Formula: C₃₀H₂₈N₄O₃
• Molecular Weight: 492.577
• Mol file: 350603-15-5.mol

Synonyms:1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Chemical Property of 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones

There total 6 articles about 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide (350603-07-5) → 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones (350603-15-5)

Guidance literature:

With copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1016/S0040-4039(01)00312-4

Reference yield:

2,4-dimethoxy-5-iodopyrimidine (52522-99-3) → 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones (350603-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

2: 62 percent / K₂CO₃; Bu₄NBr; CuI / acetonitrile / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4020(01)00637-8

Reference yield:

2-(N-benzyl-N-prop-2'-ynyl)amino-N'-p-tolylbenzamide (350603-00-8) → 1-benzyl-(E)-2-[2-(2,4-dimethoxypyrimidin-5-yl)vinyl]-3-p-tolyl-1,2,3,4-tetrahydroquinazolin-4-ones (350603-15-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 91 percent / (Ph₃P)2PdCl₂; CuI; Et₃N / acetonitrile / 16 h / 20 °C

2: 62 percent / K₂CO₃; Bu₄NBr; CuI / acetonitrile / 80 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutylammomium bromide; potassium carbonate; triethylamine; In acetonitrile;

DOI:10.1016/S0040-4020(01)00637-8

upstream raw materials:

2-[N-benzyl-N-(3'-(2,4-dimethoxypyrimidin-5-yl)prop-2'-ynyl)amino]-N'-p-tolyl benzamide

p-toluidine

2-(N-benzyl-N-prop-2'-ynyl)aminobenzoic acid

2,4-dimethoxy-5-iodopyrimidine