(S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

Base Information

Chemical Name:(S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile
CAS No.:1304773-40-7
Molecular Formula:C₃₃H₃₁FN₄O₆S
Molecular Weight:630.697
Hs Code.:

Synonyms:(S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

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Chemical Property of (S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

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Technology Process of (S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

There total 5 articles about (S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1304773-33-8
(S)-1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indoline-2,3-dione

: 109-77-3
malononitrile

: 1304773-40-7
(S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

Guidance literature:: In methanol; for 1h; Reflux; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.03.015

Reference yield:

: 1304773-43-0
1-(bromomethyl)-4-(2-(2-fluoroethoxy)ethoxy)benzene

: 1304773-40-7
(S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

1.2: 1 h / 20 °C / Inert atmosphere

2.1: methanol / 1 h / Reflux; Inert atmosphere

With sodium hydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2011.03.015

Reference yield:

: 18800-34-5
1-bromo-2-(4'-methylphenoxy)ethane

: 1304773-40-7
(S)-2-(1-(4-(2-(2-fluoroethoxy)ethoxy)benzyl)-2-oxo-5-(2-(phenoxymethyl)pyrrolidin-1-ylsulfonyl)indolin-3-ylidene)malononitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetonitrile / 24 h / Inert atmosphere; Reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2.2: 24 h / 20 - 80 °C / Inert atmosphere

3.1: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 2 h / Reflux; Inert atmosphere

4.1: sodium hydride / N,N-dimethyl-formamide / 0.25 h / 0 °C / Inert atmosphere

4.2: 1 h / 20 °C / Inert atmosphere

5.1: methanol / 1 h / Reflux; Inert atmosphere

With N-Bromosuccinimide; sodium hydride; dibenzoyl peroxide; In methanol; tetrachloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.03.015