1-(2-Bromoethoxy)-4-methylbenzene

Base Information

• Chemical Name: 1-(2-Bromoethoxy)-4-methylbenzene
• CAS No.: 18800-34-5
• Molecular Formula: C9H11 Br O
• Molecular Weight: 215.09
• Hs Code.: 29093038
• European Community (EC) Number: 882-024-9
• NSC Number: 28592
• DSSTox Substance ID: DTXSID70172142
• Wikidata: Q83042283
• Mol file: 18800-34-5.mol

Synonyms:1-(2-bromoethoxy)-4-methylbenzene;18800-34-5;1-(2-Bromo-ethoxy)-4-methyl-benzene;Benzene, 1-(2-bromoethoxy)-4-methyl-;MFCD00082852;NSC28592;p-Kresolbromathylather;SCHEMBL2414381;DTXSID70172142;2-(4-methylphenoxy)ethyl bromide;2-bromoethyl 4-methylphenyl ether;NSC 28592;NSC-28592;STL194027;AKOS000199935;AS-62742;BB 0217777;CS-0116581;FT-0717263;EN300-04672;Z56886357;F3284-8129

Chemical Property of 1-(2-Bromoethoxy)-4-methylbenzene

Chemical Property:

• Vapor Pressure: 0.0173mmHg at 25°C
• Melting Point: 37-38 °C
• Boiling Point: 107-108 °C (8 mmHg)
• Flash Point: 104.1°C
• PSA: 9.23000
• Density: 1.349g/cm³
• LogP: 2.76870
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 213.99933
• Heavy Atom Count: 11
• Complexity: 97.7

Purity/Quality:

98%min ^*data from raw suppliers

1-(2-Bromoethoxy)-4-methylbenzene ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 36/37/38-20/22
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)OCCBr

Technology Process of 1-(2-Bromoethoxy)-4-methylbenzene

There total 6 articles about 1-(2-Bromoethoxy)-4-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

p-cresol (106-44-5) + ethylene dibromide (106-93-4) → 1-bromo-2-(4'-methylphenoxy)ethane (18800-34-5)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; for 2.5h; Heating;

Reference yield: 61.0%

2-(4-methylphenoxy)ethanol (15149-10-7) → 1-bromo-2-(4'-methylphenoxy)ethane (18800-34-5)

Guidance literature:

With phosphorus tribromide;

Reference yield: 40.0%

→ 1-bromo-2-(4'-methylphenoxy)ethane (18800-34-5)

Guidance literature:

With sodium hydroxide; In water; at 130 ℃; for 16h;

upstream raw materials:

p-cresol

ethylene dibromide

potassium p-cresolate

2-(4-methylphenoxy)ethanol

Downstream raw materials:

1-(2-methoxyethoxy)-4-methylbenzene

1,1'-[ethane-1,2-diylbis(oxy)]bis(4-methylbenzene)

trimethyl-(2-p-tolyloxy-ethyl)-ammonium; bromide

7-(4'-methylphenoxy)ethyl-8-bromotheophylline

Refernces

• 1、 Gao, Yarong,Qi, Changyong,Wu, Bin,Xu, Yi,Zhong, Yan. "Synthesis of Novel Aryloxyethylamine Derivatives and Evaluation of Their in Vitro and in Vivo Neuroprotective Activities". . . Retrieved 2020/09/18.
• 2、 -. "1-aryloxy ethyl piperidine-4-yl benzophenone derivative as well as preparation method and application thereof". Paragraph 0043-0045. . Retrieved 2019/11/20.