[1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester

Base Information

• Chemical Name: [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester
• CAS No.: 925463-09-8
• Molecular Formula: C₁₂H₁₉BrNO₄PS
• Molecular Weight: 384.231
• Mol file: 925463-09-8.mol

Synonyms:[1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester

Chemical Property of [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester

There total 2 articles about [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-N-(2-methylpropylidene)-p-bromobenzenesulfinamide + methyl phosphite (96-36-6,868-85-9) → [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester (925463-09-8) + [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester

Guidance literature:

methyl phosphite; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

(S)-N-(2-methylpropylidene)-p-bromobenzenesulfinamide; In tetrahydrofuran; at -78 ℃; for 3h;

DOI:10.1016/j.bmc.2006.10.047

Reference yield:

(S)-p-bromobenzenesulfinamide (873586-57-3) → [1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester (925463-09-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: titanium(IV) ethoxide / CH₂Cl₂ / 3 h / Heating

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: tetrahydrofuran / 3 h / -78 °C

With titanium(IV) tetraethanolate; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmc.2006.10.047

Reference yield:

[1-(4-bromo-benzenesulfinylamino)-2-methyl-propyl]-phosphonic acid dimethyl ester (925463-09-8) → dimethyl (R)-N-(p-bromobenzenesulfonyl)-2-amino-2-methylpropylphosphonate (925463-08-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/j.bmc.2006.10.047

upstream raw materials:

methyl phosphite

(S)-p-bromobenzenesulfinamide

Downstream raw materials:

dimethyl (R)-N-(p-bromobenzenesulfonyl)-2-amino-2-methylpropylphosphonate