Phosphorous acid, dimethyl ester

Base Information

• Chemical Name: Phosphorous acid, dimethyl ester
• CAS No.: 96-36-6
• Molecular Formula: C2H7O3P
• Molecular Weight: 110.05
• NSC Number: 5271
• UNII: 237JNK8KUO
• DSSTox Substance ID: DTXSID20242066
• Nikkaji Number: J419.891C
• Wikidata: Q83125653
• Mol file: 96-36-6.mol

Synonyms:Phosphorous acid, dimethyl ester;96-36-6;Methyl phosphite, (MeO)2(HO)P;237JNK8KUO;Dimethyl ester phosphorous acid;NSC-5271;NSC 5271;UNII-237JNK8KUO;SCHEMBL65359;Dimethyl hydrogen phosphite #;DIMETHOXYPHOSPHINOUS ACID;Phosporous acid, dimethyl ester;DTXSID20242066;NSC5271;AKOS030228662;NCGC00249134-01

Chemical Property of Phosphorous acid, dimethyl ester

Chemical Property:

• Boiling Point: 170.5°Cat760mmHg
• Flash Point: 56.9°C
• Density: g/cm³
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 110.01328108
• Heavy Atom Count: 6
• Complexity: 28

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COP(O)OC

Technology Process of Phosphorous acid, dimethyl ester

There total 17 articles about Phosphorous acid, dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

methanol (67-56-1) → methyl phosphite (96-36-6,868-85-9)

Guidance literature:

With phosphorus trichloride; In Petroleum ether; at 50 ℃; for 1h;

Reference yield: 72.0%

phosphorous acid trimethyl ester (121-45-9) → trimethyl phosphite (512-56-1) + methyl phosphite (96-36-6,868-85-9)

Guidance literature:

With Oxone; In tetrahydrofuran; methanol; Ambient temperature;

DOI:10.1016/S0040-4039(99)00261-0

Reference yield: 63.0%

sodium tetraphenyl borate (143-66-8) + triethylamine (121-44-8) + phosphorous acid trimethyl ester (121-45-9) → methyl phosphite (96-36-6,868-85-9) + methyltriethylammonium tetraphenylborate (71162-21-5)

Guidance literature:

In acetone; at 140 ℃; for 40h; Product distribution; NaI instead NaB(C₆H₅)4;

upstream raw materials:

methanol

ethanol

dimethyl benzoylphosphonate

dimethyl sulfate

Downstream raw materials:

dimethyl 2-hydroxyethylphosphonate

dimethyl(furan-2-yl(hydroxy)methyl)phosphonate

dimethyl [(E)-1-hydroxy-3-phenyl-2-propenyl]phosphonate

O,O-diethyl S-methyl phosphorodithioate

Refernces

• 1、 Trubitsyn, Dmitry A.,Vorontsov, Alexander V.. "Catalytic vapour-phase hydrolysis and photocatalytic oxidation of dimethyl methylphosphonate on a TiO2 surface". . p. 197 - 199. Retrieved 2007/10/03.
• 2、 Li, Zhonghua,Zhu, Chuanfang,Zhao, Yongzhen. "A FACILE SYNTHESIS OF TRIALKYLSILYLPHOSPHITES AND PHOSPHATES". . p. 229 - 232. Retrieved 2007/10/02.