N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

Base Information

Chemical Name:N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine
CAS No.:1383982-02-2
Molecular Formula:C₃₄H₃₂F₂N₅O₆*Cl
Molecular Weight:680.108
Hs Code.:

Synonyms:N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

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Chemical Property of N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

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Technology Process of N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

There total 5 articles about N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.7%

: 1383981-77-8
2-bromo-N-(2,4-difluorobenzyl)-N-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]ethanamine

: 15401-69-1
berberrubine chloride

: 1383982-02-2
N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

Guidance literature:: In N,N-dimethyl-formamide; at 110 ℃; for 20h;
DOI:10.1016/j.bmc.2013.05.007

Reference yield:

: 416867-47-5
2,2'-(2,4-difluorobenzylazanediyl)diethanol

: 1383982-02-2
N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: phosphorus tribromide / chloroform / 2 h / Reflux

2.1: potassium carbonate / acetonitrile / 1 h / 60 °C

2.2: 2 h / 60 °C

3.1: N,N-dimethyl-formamide / 20 h / 110 °C

With phosphorus tribromide; potassium carbonate; In chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.05.007

Reference yield:

: 452-07-3
2,4-difluorobenzyl chloride

: 1383982-02-2
N-(2,4-difluorobenzyl)-N-(2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl)-2-(2-berberinoxyethoxy)ethanamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetonitrile / 50 °C

2.1: phosphorus tribromide / chloroform / 2 h / Reflux

3.1: potassium carbonate / acetonitrile / 1 h / 60 °C

3.2: 2 h / 60 °C

4.1: N,N-dimethyl-formamide / 20 h / 110 °C

With phosphorus tribromide; potassium carbonate; In chloroform; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmc.2013.05.007