cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

Base Information

Chemical Name:cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine
CAS No.:866141-71-1
Molecular Formula:C₁₉H₂₀Cl₂N₄
Molecular Weight:375.301
Hs Code.:

cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1<i>H</i>-pyrazolo[4,3-<i>b</i>]pyridin-7-yl]-amine

Synonyms:cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

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Chemical Property of cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

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Technology Process of cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

There total 8 articles about cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 65146-53-4
2-[2-(2,4-dichlorophenyl)-2-oxoethyl]isoindoline-1,3-dione

: 866141-71-1
cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

Guidance literature:: Multi-step reaction with 7 steps

1: 74 percent / 9 h / 82 °C

2: hydrazine monohydrochloride / ethanol; H₂O / 7 h / Heating

3: 761 g / hydrazine monohydrate / 1 h / Heating

4: p-toluenosulfonic acid / toluene / 4.5 h / Heating

5: 1.28 kg / diphenyl ether / 2 h / Heating

6: 95 percent / phosphorus oxychloride; DMF / acetonitrile / 3 h / Heating

7: p-toluenesulfonic acid / 24 h / 130 °C

With hydrazine hydrochloride; toluene-4-sulfonic acid; hydrazine hydrate; N,N-dimethyl-formamide; trichlorophosphate; In diphenylether; ethanol; water; toluene; acetonitrile;
DOI:10.1021/jm049085v

Reference yield:

: 268547-51-9
4-amino-3-(2,4-dichlorophenyl)-1H-pyrazole

: 866141-71-1
cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

Guidance literature:: Multi-step reaction with 4 steps

1: p-toluenosulfonic acid / toluene / 4.5 h / Heating

2: 1.28 kg / diphenyl ether / 2 h / Heating

3: 95 percent / phosphorus oxychloride; DMF / acetonitrile / 3 h / Heating

4: p-toluenesulfonic acid / 24 h / 130 °C

With toluene-4-sulfonic acid; N,N-dimethyl-formamide; trichlorophosphate; In diphenylether; toluene; acetonitrile;
DOI:10.1021/jm049085v

Reference yield:

: 268547-48-4
3-(2,4-dichlorophenyl)-5-methyl-7-hydroxypyrazolo-[4,3-b]pyridine

: 866141-71-1
cyclohexyl-[3-(2,4-dichloro-phenyl)-5-methyl-1H-pyrazolo[4,3-b]pyridin-7-yl]-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / phosphorus oxychloride; DMF / acetonitrile / 3 h / Heating

2: p-toluenesulfonic acid / 24 h / 130 °C

With toluene-4-sulfonic acid; N,N-dimethyl-formamide; trichlorophosphate; In acetonitrile;
DOI:10.1021/jm049085v