(S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

Base Information

Chemical Name:(S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate
CAS No.:1262536-65-1
Molecular Formula:C₂HF₃O₂*C₂₇H₂₈FN₃O₂
Molecular Weight:559.561
Hs Code.:

Synonyms:(S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

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Chemical Property of (S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

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Technology Process of (S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

There total 6 articles about (S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-8-(2-aminoethyl)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one bis(2,2,2-trifluoroacetate)

: 2243-83-6
2-naphthaloyl chloride

: 1262536-65-1
(S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

Guidance literature:: With triethylamine; In dichloromethane; Inert atmosphere;

Reference yield:

: 857680-68-3
(S)-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one

: 1262536-65-1
(S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1: MP-sodium triacetoxyborohydride resin / dichloromethane; tetrahydrofuran / Inert atmosphere

2: dichloromethane / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / Inert atmosphere

With triethylamine; In tetrahydrofuran; dichloromethane;

Reference yield:

: 857681-22-2
rac-4-(4-fluoro-phenyl)-2,8-diaza-spiro[4.5]decan-1-one hydrochloride

: 1262536-65-1
(S)-N-(2-(4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decan-8-yl)ethyl)-2-naphthamide 2,2,2-trifluoroacetate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydroxide / ethyl acetate; water / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 20 °C / Inert atmosphere

3.1: Chiraltech OJ column / isopropyl alcohol; hexanes / 1.08 h / Resolution of racemate

4.1: trifluoroacetic acid / dichloromethane / Inert atmosphere

4.2: Inert atmosphere

5.1: MP-sodium triacetoxyborohydride resin / dichloromethane; tetrahydrofuran / Inert atmosphere

6.1: dichloromethane / 20 °C / Inert atmosphere

7.1: triethylamine / dichloromethane / Inert atmosphere

With triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; hexanes; dichloromethane; water; ethyl acetate; isopropyl alcohol;