rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Base Information

Chemical Name:rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester
CAS No.:857680-66-1
Molecular Formula:C₁₉H₂₅FN₂O₃
Molecular Weight:348.418
Hs Code.:

Synonyms:rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

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Chemical Property of rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

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Technology Process of rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

There total 8 articles about rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 876592-60-8
rac-4-(2-arnino-1-phenyl-ethyl)-1-tert-butyl-piperidine-1,4-dicarboxylic acid ethyl ester

: 857680-66-1
rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Guidance literature:: In toluene; for 18h; Heating;
DOI:10.1055/s-2005-918454

Reference yield: 82.0%

: 857680-63-8
rac-4-(4-fluorophenyl)-2,8-diazaspiro[4.5]decan-1-one

: 24424-99-5
di-tert-butyl dicarbonate

: 857680-66-1
rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃; Inert atmosphere;

Reference yield:

: 857680-64-9
rac-4-[1-(4-fluorophenyl)-2-nitroethyl]piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester

: 857680-66-1
rac-4-(4-fluorophenyl)-1-oxo-2,8-diazaspiro[4.5]decane-8-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 99 percent / H₂ / Ra-Ni / ethanol / 20 h / 50 °C / 37503 Torr

2: 83 percent / toluene / 18 h / Heating

With hydrogen; Ra-Ni; In ethanol; toluene;
DOI:10.1055/s-2005-918454