methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

Base Information

Chemical Name:methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate
CAS No.:1321908-64-8
Molecular Formula:C₁₈H₁₈O₅S
Molecular Weight:346.404
Hs Code.:

Synonyms:methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

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Chemical Property of methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

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Technology Process of methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

There total 3 articles about methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1321908-50-2
methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

: 1321908-64-8
methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With silver hexafluoroantimonate; (N'-(^tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/chem.201100305

Reference yield:

: 34097-60-4
methyl benzenesulfonylacetate

: 1321908-64-8
methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate / acetone; toluene / 16 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 1 h / 65 °C / Inert atmosphere

3.1: silver hexafluoroantimonate; (N'-(^tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; (N'-(^tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; acetone; toluene; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1002/chem.201100305

Reference yield:

: 1311267-47-6
methyl 2-(phenylsulfonyl)-2-(prop-2-ynyl)pent-4-ynoate

: 1321908-64-8
methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / Inert atmosphere

1.2: 1 h / 65 °C / Inert atmosphere

2.1: silver hexafluoroantimonate; (N'-(^tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride / dichloromethane / 1 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; silver hexafluoroantimonate; (N'-(^tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride; triethylamine; In tetrahydrofuran; dichloromethane; 1.1: Sonogashira coupling / 1.2: Sonogashira coupling;
DOI:10.1002/chem.201100305