methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

Base Information

Chemical Name:methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate
CAS No.:1321908-50-2
Molecular Formula:C₁₈H₁₈O₅S
Molecular Weight:346.404
Hs Code.:

Synonyms:methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

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Chemical Property of methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

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Technology Process of methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

There total 2 articles about methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 84201-43-4
2-iodoprop-2-en-1-ol

: 1311267-47-6
methyl 2-(phenylsulfonyl)-2-(prop-2-ynyl)pent-4-ynoate

: 1321908-50-2
methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

Guidance literature:: 2-iodoprop-2-en-1-ol; methyl 2-(phenylsulfonyl)-2-(prop-2-ynyl)pent-4-ynoate; With bis-triphenylphosphine-palladium(II) chloride; triethylamine; In tetrahydrofuran; for 0.166667h; Inert atmosphere;

With copper(l) iodide; In tetrahydrofuran; at 65 ℃; for 1h; Inert atmosphere;
DOI:10.1002/chem.201100305

Reference yield:

: 34097-60-4
methyl benzenesulfonylacetate

: 1321908-50-2
methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: caesium carbonate / acetone; toluene / 16 h / 20 °C

2.1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran / 0.17 h / Inert atmosphere

2.2: 1 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; triethylamine; In tetrahydrofuran; acetone; toluene; 2.1: Sonogashira coupling / 2.2: Sonogashira coupling;
DOI:10.1002/chem.201100305

Reference yield: 49.0%

: 1321908-50-2
methyl 6-(hydroxymethyl)-2-(phenylsulfonyl)-2-(prop-2-ynyl)hept-6-en-4-ynoate

: 1321908-64-8
methyl 5-hydroxy-6-methyl-2-(phenylsulfonyl)-2,3-dihydro-1H-indene-2-carboxylate

Guidance literature:: With silver hexafluoroantimonate; (N'-(^tbutyl)-N,N-diethylcarbamimidoyl)gold(I) chloride; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1002/chem.201100305