(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

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Chemical Name:(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester
CAS No.:1028270-75-8
Molecular Formula:C₃₉H₄₂FN₅O₉
Molecular Weight:743.789
Hs Code.:

(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

Synonyms:(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

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Chemical Property of (E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

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Technology Process of (E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

There total 11 articles about (E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6332-56-5
2-hydroxy-3-nitropyridine

: 1028270-75-8
(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: H₂ / 10percent Pd/C / ethanol / 16 h / 760.05 Torr

2.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

3.1: NaH / tetrahydrofuran / 23 °C

3.2: tetrahydrofuran / Heating

4.1: aq. HF / acetonitrile / 23 °C

5.1: Dess-Martin periodinane / CH₂Cl₂ / 23 °C

6.1: tetrahydrofuran / 1.75 h / Heating

With hydrogen fluoride; hydrogen; sodium hydride; Dess-Martin periodane; 10percent Pd/C; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 33630-99-8
2-hydroxy-3-aminopyridine

: 1028270-75-8
(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 65 percent / acetonitrile / 1.67 h / 0 - 23 °C

2.1: NaH / tetrahydrofuran / 23 °C

2.2: tetrahydrofuran / Heating

3.1: aq. HF / acetonitrile / 23 °C

4.1: Dess-Martin periodinane / CH₂Cl₂ / 23 °C

5.1: tetrahydrofuran / 1.75 h / Heating

With hydrogen fluoride; sodium hydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k

Reference yield:

: 223526-33-8
(1S,3'S)-<2-<1'-(2'',4''-dimethoxybenzyl)-2'-oxo-pyrrolidin-3'-yl>-1-hydroxymethylethyl>-carbamic acid tert-butyl ester

: 1028270-75-8
(E)-(S)-5-[(S)-1-(2,4-Dimethoxy-benzyl)-2-oxo-pyrrolidin-3-yl]-4-((S)-3-(4-fluoro-phenyl)-2-{3-[(5-methyl-isoxazole-3-carbonyl)-amino]-2-oxo-2H-pyridin-1-yl}-propionylamino)-pent-2-enoic acid ethyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: 50 percent / Et₃N; 4-(dimethylamino)pyridine / CH₂Cl₂ / 2 h / 23 °C

2.1: HCl / dioxane / 1.25 h / 23 °C

3.1: 4-methylmorpholine; HATU / acetonitrile / 23 °C

4.1: N,N-diisopropylethylamine / CH₂Cl₂ / -10 °C

5.1: NaH / tetrahydrofuran / 23 °C

5.2: tetrahydrofuran / Heating

6.1: aq. HF / acetonitrile / 23 °C

7.1: Dess-Martin periodinane / CH₂Cl₂ / 23 °C

8.1: tetrahydrofuran / 1.75 h / Heating

With 4-methyl-morpholine; hydrogenchloride; dmap; hydrogen fluoride; sodium hydride; Dess-Martin periodane; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; acetonitrile;
DOI:10.1021/jm010469k