N,N'-Dimethyl-1,2-cyclohexanediamine

Base Information

• Chemical Name: N,N'-Dimethyl-1,2-cyclohexanediamine
• CAS No.: 61798-24-1
• Molecular Formula: C8H18N2
• Molecular Weight: 142.244
• Hs Code.: 29213099
• Mol file: 61798-24-1.mol

Synonyms:1,2-Cyclohexanediamine,N,N'-dimethyl- (9CI);N,N'-Dimethyl-1,2-diaminocyclohexane;

Chemical Property of N,N'-Dimethyl-1,2-cyclohexanediamine

Chemical Property:

• Appearance/Colour: Clear colorless to slightly yellow liquid
• Refractive Index: n20/D 1.472(lit.)
• Boiling Point: 186.8 °C at 760 mmHg
• PKA: 11.04±0.40(Predicted)
• Flash Point: 60.2 °C
• PSA: 24.06000
• Density: 0.89 g/cm³
• LogP: 1.51820
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%, ^*data from raw suppliers

N,?N''-?Dimethyl-?1,?2-?cyclohexanediamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 22-34
• Safety Statements: 26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N,?N''-?Dimethyl-?1,?2-?cyclohexanediamine is used as a catalyst in the synthesis of substituted pyrazoles with anti-inflammatory activity. As well as highly functional pyridines and bipyridines.

Technology Process of N,N'-Dimethyl-1,2-cyclohexanediamine

There total 17 articles about N,N'-Dimethyl-1,2-cyclohexanediamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

N,N’-[(±)-trans-cyclohexane-1,2-diyl]diformamide → trans-N,N'-dimethylcyclohexane-1,2-diamine (61798-24-1,67579-81-1,68737-65-5,75599-23-4,87583-89-9,99295-66-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 65 ℃; for 16h;

DOI:10.1021/ja027433h

Reference yield: 42.0%

trans-N,N'-dimethylcyclohexane-1,2-diamine (61798-24-1,67579-81-1,68737-65-5,75599-23-4,87583-89-9,99295-66-6) → (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane (61798-24-1,67579-81-1,68737-65-5,75599-23-4,99295-66-6,87583-89-9)

Guidance literature:

trans-N,N'-dimethylcyclohexane-1,2-diamine; With L-Tartaric acid; In ethanol; at 20 ℃; for 1h; Reflux; Resolution of racemate;

With potassium hydroxide; In dichloromethane; at 20 ℃; pH=9-10; Reflux; Resolution of racemate;

DOI:10.3184/174751913X13626731204890

Reference yield: 39.0%

→ (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane (68737-65-5) + (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane (61798-24-1,67579-81-1,68737-65-5,75599-23-4,99295-66-6,87583-89-9)

Guidance literature:

upstream raw materials:

(S,S)-1,2-diaminocyclohexane-N,N'-diethyl carbamate

N-((1S,2S)-2-Formylamino-cyclohexyl)-formamide

(S,S)-1,2-diaminocyclohexane

7-methyl-7-azabicyclo[4.1.0]heptane

Downstream raw materials:

(3aS,7aS)-2<(1R)-methyl-2-phenylethyl>-<3a,4,5,6,7,7a-octahydro-1,3-dimethyl-1,3,2-benzodiazaphosphole>-2-oxide

(3aS,7aS)-2<(1S)-methyl-2-phenylethyl>-<3a,4,5,6,7,7a-octahydro-1,3-dimethyl-1,3,2-benzodiazaphosphole>-2-oxide

N-(2-aminophenyl)indole

N-(2-pyridyl)indole