(S,E)-N⁽⁸⁾-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N⁽¹⁾-(quinolin-8-yl)octanediamide

Base Information

• Chemical Name: (S,E)-N⁽⁸⁾-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N⁽¹⁾-(quinolin-8-yl)octanediamide
• CAS No.: 1260377-76-1
• Molecular Formula: C₃₄H₃₆N₄O₅
• Molecular Weight: 580.684

Synonyms:(S,E)-N⁽⁸⁾-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N⁽¹⁾-(quinolin-8-yl)octanediamide

Chemical Property of (S,E)-N⁽⁸⁾-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N⁽¹⁾-(quinolin-8-yl)octanediamide

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Technology Process of (S,E)-N⁽⁸⁾-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N⁽¹⁾-(quinolin-8-yl)octanediamide

There total 1 articles about (S,E)-N⁽⁸⁾-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N⁽¹⁾-(quinolin-8-yl)octanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

(S,E)-methyl 7-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-8-oxo-8-(quinolin-8-ylamino)octanoate (1260378-07-1) → (S,E)-N(8)-hydroxy-2-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-N(1)-(quinolin-8-yl)octanediamide (1260377-76-1)

Guidance literature:

With hydroxylamine hydrochloride; potassium tert-butylate; In methanol; at 22 ℃;

DOI:10.1016/j.bmcl.2010.09.096

upstream raw materials:

(S,E)-methyl 7-(3-(4-(4-methylbenzyloxy)phenyl)acrylamido)-8-oxo-8-(quinolin-8-ylamino)octanoate

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