Chemical Property of Nefazodone
Chemical Property:
- Appearance/Colour:White to off-white crystalline powder
- Melting Point:186 - 188 C
- Boiling Point:599.6±60.0 °C(Predicted)
- PKA:pKa 6.5 (Uncertain)
- PSA：55.53000
- Density:1.23±0.1 g/cm3(Predicted)
- LogP:3.55480
- Storage Temp.:2-8°C
- Solubility.:DMSO: ~11 mg/mL at 60 °C
- XLogP3:4.3
- Hydrogen Bond Donor Count:0
- Hydrogen Bond Acceptor Count:5
- Rotatable Bond Count:10
- Exact Mass:469.2244530
- Heavy Atom Count:33
- Complexity:649
- Purity/Quality:
-
99%, *data from raw suppliers
NefazodoneHCl *data from reagent suppliers
Safty Information:
- Pictogram(s):
UN NO.
- Hazard Codes:UN NO.
- Safety Statements:
22-24/25
- MSDS Files:
-
SDS file from LookChem
Useful:
- Drug Classes:Antidepressant Agents
- Canonical SMILES:CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
- Recent ClinicalTrials:Effectiveness of Nefazodone and Bupropion in Treating Marijuana Dependent Individuals
-
Uses
A selective serotonin 5-HT2 receptor antagonist. An antidepressant
-
Therapeutic Function
Antidepressant
-
Biological Functions
Although nefazodone (Serzone) is structurally related
to trazodone, it is less sedating. It does not block α1-
adrenoreceptors, and its use is not associated with priapism.
Nefazodone inhibits the neuronal reuptake of
serotonin and blocks 5HT2A receptors. Its short half-life
requires dosing twice a day. Nefazodone is
not associated with weight gain or sexual dysfunction. It
inhibits the cytochrome P450 3A4 isoenzyme that is responsible
for 50% of known oxidative metabolism, and
therefore, nefazodone can elevate levels of drugs dependent
on this pathway for metabolism.
