CAS No.83366-66-9,Nefazodone Suppliers

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Basic Information

Molecular Structure:
CAS No.:	83366-66-9
Name:	Nefazodone
Article Data:	1

Formula:	C25H32 Cl N5 O2
Molecular Weight:	470.014
Synonyms:	Nefazodone
Density:	1.23±0.1 g/cm3(Predicted)
Melting Point:	186 - 188 C
Boiling Point:	599.6±60.0 °C(Predicted)
Solubility:	Slightly soluble White to off-white crystalline powder
Hazard Symbols:	UN NO.
PSA:	55.53000
LogP:	3.55480

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Chemistry

Molecular Formula: C₂₅H₃₂ClN₅O₂Molecular Weight: 470.01
Index of Refraction: 1.616
Density: 1.23 g/cm³
Flash Point: 316.4 °C
Melting Point: 180-182°C
Appearance: white solid
Solubility: DMSO: ~11 mg/mL at 60 °C
Enthalpy of Vaporization: 89.26 kJ/mol
Boiling Point: 599.6 °C at 760 mmHg
Vapour Pressure: 2.46E-14 mmHg at 25°C
IUPAC Name: 2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
Synonyms: 3H-1,2,4-triazol-3-one,2,4-dihydro-2-3-(4-(3-chlorophenyl)-1-piperazinyl)propy;l)-5-ethyl-4-(2-phenoxyethyl)- ; BMY-13754 ; 2-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-5-ethyl-2,4-dihydro-4-(2-phenoxyethyl)-3H-1,2,4-triazol-3-one hydrochloride ; Serzone ; MJ-13754-1 ; Nefazodone ; Nefazodone base
Following is the molecular structure of Nefazodone hydrochloride (83366-66-9):

Toxicity Data With Reference

The toxicity of Nefazodone hydrochloride (83366-66-9):

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
man	TDLo	oral	40mg/kg/2W-I (40mg/kg)	PERIPHERAL NERVE AND SENSATION: PARESTHESIS	Journal of Clinical Psychiatry. Vol. 61, Pg. 216, 2000.
women	TDLo	oral	28mg/kg/1W-I (28mg/kg)	BEHAVIORAL: TOXIC PSYCHOSIS BEHAVIORAL: EXCITEMENT BEHAVIORAL: ALTERATION OF OPERANT CONDITIONING	American Journal of Psychiatry. Vol. 154, Pg. 578, 1997.

Safety Profile

Safety Information of Nefazodone hydrochloride (83366-66-9):
Safety Statements: 22-24/25
22: Do not breathe dust
24/25: Avoid contact with skin and eyes
WGK Germany: 3

Specification

Side effects of Nefazodone hydrochloride (83366-66-9): Unlike most serotonin reuptake inhibitors, Nefazodone usually has no negative effects on libido or sexual functioning, and is actually sometimes used as an antidote to SSRI or SNRI induced impotence and anorgasmia in men. More serious side effects include an allergic reaction, fainting, or painful/prolonged erection. Less serious reactions of nefazodone include dizziness, lightheadedness, fatigue, upset stomach, insomnia; dry mouth; constipation; or blurred/abnormal vision.
Advantages of Nefazodone hydrochloride (83366-66-9): Nefazodone, though an antidepressant, may also be beneficial in the prophylaxis of migraines due to its antagonistic effects on the 5-HT2A and 5-HT2C receptors It has a more favorable side effect profile than amitriptyline, a tricyclic antidepressant commonly used for migraine prophylaxis.