O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate

Base Information

• Chemical Name: O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate
• CAS No.: 1192761-59-3
• Molecular Formula: C₁₄H₂₀NO₃PS
• Molecular Weight: 313.357
• Mol file: 1192761-59-3.mol

Synonyms:O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate

Chemical Property of O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate

There total 6 articles about O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.4%

carbon disulfide (75-15-0,12122-00-8) + diisopropyl [amino(phenyl)methyl]phosphonate (112564-57-5) → O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate (1192761-59-3)

Guidance literature:

With bis(trichloromethyl) carbonate; triethylamine; In diethyl ether;

DOI:10.1016/j.ejmech.2010.08.021

Reference yield:

benzaldehyde (100-52-7) → O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate (1192761-59-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: ammonium hydroxide / water / 5 h / Inert atmosphere; Reflux

2.1: 70 °C / Inert atmosphere; Neat (no solvent)

3.1: toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: Inert atmosphere

4.2: 4 h / 0 - 25 °C / Inert atmosphere

4.3: 2 h / 25 °C / Inert atmosphere

With ammonium hydroxide; toluene-4-sulfonic acid; In tetrahydrofuran; water;

DOI:10.1007/s11426-010-4179-5

Reference yield:

hydrobenzamide (92-29-5) → O,O'-diisopropyl isothiocyanato(phenyl)methylphosphonate (1192761-59-3)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 70 °C / Inert atmosphere; Neat (no solvent)

2.1: toluene-4-sulfonic acid / tetrahydrofuran / 2 h / 0 °C / Inert atmosphere

2.2: 0.5 h / 20 °C / Inert atmosphere

3.1: Inert atmosphere

3.2: 4 h / 0 - 25 °C / Inert atmosphere

3.3: 2 h / 25 °C / Inert atmosphere

With toluene-4-sulfonic acid; In tetrahydrofuran;

DOI:10.1007/s11426-010-4179-5

upstream raw materials:

carbon disulfide

diisopropyl [amino(phenyl)methyl]phosphonate

C₂₀H₂₆NO₃P

benzaldehyde

Downstream raw materials:

O,O'-diisopropyl phenyl[3-((S)-1-phenylethyl)thioureido]methylphosphonate

O,O'-diisopropyl phenyl[3-((R)-1-phenylethyl)thioureido]methylphosphonate

O,O'-diisopropyl phenyl[3-((S)-1-cyclohexylethyl)thioureido]methylphosphonate

O,O'-diisopropyl phenyl[3-((R)-1-cyclohexylethyl)thioureido]methylphosphonate