N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

Base Information

Chemical Name:N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide
CAS No.:1422431-30-8
Molecular Formula:C₂₆H₂₇NO₆
Molecular Weight:449.503
Hs Code.:

Synonyms:N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

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Chemical Property of N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

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Technology Process of N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

There total 8 articles about N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 7-(benzyloxy)-8-methoxyisochromen-3-one

: 1484-85-1
3,4-methylenedioxyphenylethylamine

: 1422431-30-8
N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

Guidance literature:: In ethanol; for 14h; Reflux;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 14199-15-6
Methyl 4-hydroxyphenylacetate

: 1422431-30-8
N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; bromine / 2 h / 20 °C

2.1: potassium carbonate / acetone / Reflux

3.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: phenylboronic acid / toluene / 1 h / Reflux; Dean-Stark

4.2: 46 h / 100 °C / Molecular sieve; Sealed tube

4.3: 2 h / Reflux

5.1: potassium carbonate / acetone / 4 h / Reflux

6.1: ethanol / 14 h / Reflux

With water; bromine; copper; potassium carbonate; acetic acid; copper(II) oxide; potassium hydroxide; phenylboronic acid; In ethanol; acetone; toluene;
DOI:10.1016/j.bmc.2012.12.016

Reference yield:

: 34918-57-5
methyl 3-bromo-4-hydroxyphenylacetate

: 1422431-30-8
N-(2-(benzo[d][1,3]dioxol-5-yl)ethyl)-2-(3-(benzyloxy)-2-(hydroxymethyl)-4-methoxyphenyl)acetamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / acetone / Reflux

2.1: potassium hydroxide; water; copper; copper(II) oxide / 1 h / 140 °C / Inert atmosphere; Microwave irradiation

3.1: phenylboronic acid / toluene / 1 h / Reflux; Dean-Stark

3.2: 46 h / 100 °C / Molecular sieve; Sealed tube

3.3: 2 h / Reflux

4.1: potassium carbonate / acetone / 4 h / Reflux

5.1: ethanol / 14 h / Reflux

With water; copper; potassium carbonate; copper(II) oxide; potassium hydroxide; phenylboronic acid; In ethanol; acetone; toluene;
DOI:10.1016/j.bmc.2012.12.016