34918-57-5

Upstream product

• 67-56-1 methanol 
• 38692-80-7 2-(3-bromo-4-hydroxyphenyl)acetic acid 
• 14199-15-6 Methyl 4-hydroxyphenylacetate 
• 156-38-7 4-hydroxyphenylacetate 
• 42058-59-3 3-hydroxy-benzeneacetic acid, methyl ester 

Downstream Products

• 38692-80-7 2-(3-bromo-4-hydroxyphenyl)acetic acid 
• 774-81-2 (3-bromo-4-methoxy-phenyl)-acetic acid 
• 19626-36-9 methyl 2-(3-bromo-4-methoxyphenyl)acetate 
• 185200-35-5 (3-Bromo-4-methanesulfonyloxy-phenyl)-acetic acid methyl ester 
• 544478-37-7 [3-Bromo-4-(3-bromo-propoxy)-phenyl]-acetic acid methyl ester 
• 101111-25-5 methyl 2-(4-(benzyloxy)-3-bromophenyl)acetate 
• 234757-51-8 ethyl 2-(4-(benzyloxy)-3-bromophenyl)acetate 
• 222843-69-8 2-(4-Benzyloxy-3-bromophenyl)-1-ethanol 
• 234757-52-9 2-(4-Benzyloxy-3-bromophenyl)-1-iodoethane 
• 222843-40-5 6-Benzyloxy-5-bromo-2,3-dihydrobenzothiophene 
• 222843-62-1 Benzyl 2-(4-benzyloxy-3-bromophenyl)ethyl sulfide 
• 131926-21-1 2-{2-Bromo-4-[2-(2-methoxy-ethoxymethoxy)-ethyl]-phenoxy}-tetrahydro-pyran 
• 131926-26-6 2-[(2R,3R,3aS,8bR)-3-Allyl-2-(tert-butyl-diphenyl-silanyloxy)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-7-yl]-ethanol 
• 131926-27-7 [(2R,3R,3aS,8bR)-3-Allyl-2-(tert-butyl-diphenyl-silanyloxy)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan-7-yl]-acetic acid methyl ester 

Relevant academic research and scientific papers

Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite Plasmodium falciparum and Optimization Efforts

A novel diazaspiro[3.4]octane series was identified from a Plasmodium falciparum whole-cell high-throughput screening campaign. Hits displayed activity against multiple stages of the parasite lifecycle, which together with a novel sp3-rich scaffold provided an attractive starting point for a hit-to-lead medicinal chemistry optimization and biological profiling program. Structure-activity-relationship studies led to the identification of compounds that showed low nanomolar asexual blood-stage activity (50 nM) together with strong gametocyte sterilizing properties that translated to transmission-blocking activity in the standard membrane feeding assay. Mechanistic studies through resistance selection with one of the analogues followed by whole-genome sequencing implicated the P. falciparum cyclic amine resistance locus in the mode of resistance.

Preparation method of isoquinoline alkaloid L-corydalmine

The invention belongs to the field of medical chemistry, and provides a preparation method of L-corydalmine or pharmaceutically acceptable salts thereof. The method comprises the following steps of: in the presence of an organic solvent, catalyzing by pal

Therapeutic use of benzylidene tetrahydropyridine derivatives

The invention belongs to the technical field of pharmaceutical and relates to therapeutic use of benzylidene tetrahydropyridine derivatives, specifically use of berberine derivatives for resisting diabetes, reducing blood fat and cholesterol, and treating cardiovascular diseases, particularly use of resisting diabetes.

DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF

The present invention relates to a diarylo[a,g]quinolizidine compound of formula (I), enantiomer, diastereoisomer, racemate, mixture, pharmaceutically acceptable salt, crystalline hydrate or solvate thereof; the preparation method thereof, and uses thereof in preparing an experimental model drugs related to dopamine receptors and 5-HT receptors or a medicament for treating or preventing a disease related to dopamine receptors and 5-HT receptors.

DIARYL[A, G]QUINOLIZIDINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION, AND USES THEREOF

The present invention relates to a diarylo[a,g]quinolizidine compound of formula (I), enantiomer, diastereoisomer, racemate, mixture, pharmaceutically acceptable salt, crystalline hydrate or solvate thereof; the preparation method thereof, and uses thereof in preparing an experimental model drugs related to dopamine receptors and 5-HT receptors or a medicament for treating or preventing a disease related to dopamine receptors and 5-HT receptors.

Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis B virus infection

The invention provides novel compounds having the general formula: wherein R1, R2, R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds.

NOVEL DIHYDROQUINOLIZINONES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

The invention provides novel compounds having the general formula (I) wherein R1, R2 R3, R4, R5 and R6 are as described herein, compositions including the compounds and methods of using the compounds in the treatment of the hepatitis B virus.

Synthesis of (+)-O-methylthalibrine by employing a stereocontrolled Bischler-Napieralski reaction and an electrochemically generated diaryl ether

An efficient electrochemical four-step route was developed for the preparation of diaryl ether derivatives by using halogenation and dehalogenation processes in addition to electrochemical phenolic oxidation and reduction reactions. The synthesis of (+)-O

HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION AND USE THEREOF

The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The present invention further relates to a method for preparing the compound, and the compound has good prevention and treatment effect on neurological diseases, especially diseases associated with dopamine receptor and 5-hydroxytryptamine receptor. The bioactivity experiment demonstrates that, the compound is expected to be developed into a novel and potent chemical entity for treating diseases associated with dopamine receptor and 5-hydroxytryptamine receptor, especially schizophrenia, Parkinson's disease, drug addiction, migraine and so on.

HEXAHYDRODIBENZO[A,G]QUINOLIZINE COMPOUND, PREPARATION METHOD THEREOF, PHARMACEUTICAL COMPOSITION AND USE THEREOF

The present invention relates to a novel hexahydrodibenzo[a,g]quinoline compound represented by general formula (I) and its derivatives, enantiomer, diastereoisomer, raceme and mixtures thereof, as well as pharmaceutically acceptable salts thereof. The pr