2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

Base Information

Chemical Name:2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime
CAS No.:791845-56-2
Molecular Formula:C₅₃H₁₀₂N₂O₁₄Si₂
Molecular Weight:1047.57
Hs Code.:

Synonyms:2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

Suppliers and Price of 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

There total 1 articles about 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 206997-61-7
E-2',4-O-bis(trimethylsilyl)erythromycin A 9-O-(1-isopropyloxycyclohexyl)oxime

: 74-88-4
methyl iodide

: 791845-56-2
2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

Guidance literature:: E-2',4"-O-bis(trimethylsilyl)erythromycin A 9-O-(1-isopropyloxycyclohexyl)oxime; methyl iodide; With potassium hydroxide; In Isopropyl acetate; dimethyl sulfoxide; at 5 - 10 ℃; for 1.5h;

With methylamine; In Isopropyl acetate; water; dimethyl sulfoxide; for 0.25h; Product distribution / selectivity;

Reference yield:

: 791845-56-2
2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

: 81103-11-9
clarithromycin

Guidance literature:: 2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime; With formic acid; In ethanol; water; at 40 - 45 ℃; for 3h; pH=2.5 - 3.5;

With sodium hydrogensulfite; In ethanol; water; for 1h; Product distribution / selectivity; Heating / reflux;

Reference yield:

: 791845-56-2
2',4-O-bis(trimethylsilyl)-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)-oxime

: 1360059-74-0
2'-O-trimethylsilyl-3-O-descladinosyl-3-O-allyl-6-O-methylerythromycin A 9-(E)-O-(1-isopropoxycyclohexyl)oxime

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / ethanol; water / 1 h / 40 °C

1.2: pH 9

2.1: pyridine hydrochloride / acetonitrile / 3 h / 20 °C

2.2: 0.67 h / 0 °C

3.1: potassium tert-butylate / N,N-dimethyl-formamide / 0.12 h / 20 °C

With hydrogenchloride; potassium tert-butylate; pyridine hydrochloride; In ethanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.01.023