Technology Process of 5,8aβ-dimethyl-2α-phenylselenenyl-3,4,4aα,7,8,8a-hexahydro-1<2H>-naphthalenone
There total 7 articles about 5,8aβ-dimethyl-2α-phenylselenenyl-3,4,4aα,7,8,8a-hexahydro-1<2H>-naphthalenone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
methyllithium; diisopropylamine;
In
tetrahydrofuran; hexane;
at -78 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / DABCO / 1,2-dimethoxy-ethane / 12 h / Ambient temperature
2: 89 percent / triethylamine, benzoic acid / xylene / 22 h / Heating
3: 88 percent / p-toluenesulfonic acid / benzene / Heating
4: 69 percent / Li/NH3, N,N,N',N'-tetramethylenediamine, diethyl phosphorochloridate / diethyl ether; 2-methyl-propan-2-ol / 1.) -78 deg C, 1.5 h; 2.) 0 deg C, 5 h
5: 84 percent / Li wire, ethylamine, tert-butyl alcohol / tetrahydrofuran / 2 h / 0 °C
6: 100 percent / p-toluenesulfonic acid / acetone / 16 h / Ambient temperature
7: 88 percent / diisopropylamine, methyllithium / tetrahydrofuran; hexane / 3 h / -78 °C
With
1,4-diaza-bicyclo[2.2.2]octane; N,N,N,N,-tetramethylethylenediamine; ammonia; methyllithium; lithium; diethyl chlorophosphate; toluene-4-sulfonic acid; ethylamine; triethylamine; diisopropylamine; benzoic acid; tert-butyl alcohol;
toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; acetone; xylene; tert-butyl alcohol; benzene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 90 percent / DABCO / 1,2-dimethoxy-ethane / 12 h / Ambient temperature
2: 89 percent / triethylamine, benzoic acid / xylene / 22 h / Heating
3: 88 percent / p-toluenesulfonic acid / benzene / Heating
4: 69 percent / Li/NH3, N,N,N',N'-tetramethylenediamine, diethyl phosphorochloridate / diethyl ether; 2-methyl-propan-2-ol / 1.) -78 deg C, 1.5 h; 2.) 0 deg C, 5 h
5: 84 percent / Li wire, ethylamine, tert-butyl alcohol / tetrahydrofuran / 2 h / 0 °C
6: 100 percent / p-toluenesulfonic acid / acetone / 16 h / Ambient temperature
7: 88 percent / diisopropylamine, methyllithium / tetrahydrofuran; hexane / 3 h / -78 °C
With
1,4-diaza-bicyclo[2.2.2]octane; N,N,N,N,-tetramethylethylenediamine; ammonia; methyllithium; lithium; diethyl chlorophosphate; toluene-4-sulfonic acid; ethylamine; triethylamine; diisopropylamine; benzoic acid; tert-butyl alcohol;
toluene-4-sulfonic acid;
In
tetrahydrofuran; 1,2-dimethoxyethane; diethyl ether; hexane; acetone; xylene; tert-butyl alcohol; benzene;
