(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Base Information

Chemical Name:(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine
CAS No.:1380423-99-3
Molecular Formula:C₃₅H₄₃F₃N₂O₂Si₂
Molecular Weight:636.905
Hs Code.:

Synonyms:(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

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Chemical Property of (S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

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Technology Process of (S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

There total 7 articles about (S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1380423-98-2
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

: 1380423-99-3
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Guidance literature:: With iodine; triethylamine; In methanol; for 0.5h; Inert atmosphere;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1380423-99-3
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide

1.2: 0 °C

2.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / -78 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

3.2: Inert atmosphere

4.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

6.1: ammonia / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Sealed tube

7.1: triethylamine; iodine / methanol / 0.5 h / Inert atmosphere

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; ammonia; iodine; sodium methylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 895153-57-8
(S)-1-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)pent-4-yn-2-ol

: 1380423-99-3
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)-3H-diazirine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

1.2: Inert atmosphere

2.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

4.1: ammonia / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Sealed tube

5.1: triethylamine; iodine / methanol / 0.5 h / Inert atmosphere

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonia; iodine; sodium methylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;