(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

Base Information

Chemical Name:(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine
CAS No.:1380423-98-2
Molecular Formula:C₃₅H₄₅F₃N₂O₂Si₂
Molecular Weight:638.921
Hs Code.:

Synonyms:(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

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Chemical Property of (S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

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Technology Process of (S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

There total 6 articles about (S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1380423-96-0
(S)-1-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-2,2,2-trifluoroethanone

: 1380423-98-2
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

Guidance literature:: With ammonia; In tetrahydrofuran; at 20 ℃; for 48h; Inert atmosphere; Sealed tube;

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 1380423-98-2
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide

1.2: 0 °C

2.1: n-butyllithium; boron trifluoride diethyl etherate / tetrahydrofuran / -78 °C / Inert atmosphere

3.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

3.2: Inert atmosphere

4.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

5.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

6.1: ammonia / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Sealed tube

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; n-butyllithium; boron trifluoride diethyl etherate; ammonia; sodium methylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 895153-57-8
(S)-1-(tert-butyldiphenylsilyloxy)-5-(trimethylsilyl)pent-4-yn-2-ol

: 1380423-98-2
(S)-3-(4-(4-(tert-butyldimethylsilyloxy)-5-(tert-butyldiphenylsilyloxy )pent-1-ynyl)phenyl)-3-(trifluoromethyl)diaziridine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / Inert atmosphere

1.2: Inert atmosphere

2.1: methanol; sodium methylate / methanol / 1 h / 20 °C / Inert atmosphere

3.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

4.1: ammonia / tetrahydrofuran / 48 h / 20 °C / Inert atmosphere; Sealed tube

With 1H-imidazole; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; ammonia; sodium methylate; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;