{4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Base Information

Chemical Name:{4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane
CAS No.:1351305-64-0
Molecular Formula:C₂₉H₄₆O₃Si
Molecular Weight:470.768
Hs Code.:

Synonyms:{4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Suppliers and Price of {4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

There total 9 articles about {4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 2186-92-7
p-Anisaldehyde dimethyl acetal

: 1351305-63-9
(3R,4S,6R)-3,6-dimethyl-10-[tris(propan-2-yl)silyl]dec-1-en-9-yne-4,6-diol

: 1351305-64-0
{4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol203064r

Reference yield:

: 763-32-6
2-methyl-1-buten-4-ol

: 1351305-64-0
{4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Guidance literature:: Multi-step reaction with 9 steps

1.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere; Reflux

2.1: asymmetric dihydroxylation-mix-α; hydroquinidein 1,4-phthalazinediyl diether / water; tert-butyl alcohol / 24 h / 0 °C / Inert atmosphere

3.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0.75 h / 0 °C / Inert atmosphere

3.2: 0.5 h / 0 - 20 °C / Inert atmosphere

4.1: magnesium; mercury dichloride / diethyl ether; toluene / 0 - 10 °C / Inert atmosphere

4.2: 1 h / 0 - 20 °C / Inert atmosphere

5.1: methylmagnesium bromide / tetrahydrofuran; diethyl ether / 6 h / 70 °C / Inert atmosphere

5.2: 5 h / 75 °C / Inert atmosphere

6.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.5 h / 0 - 20 °C / Inert atmosphere

7.1: sodium hypochlorite; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; potassium bromide / dichloromethane; water / 0.5 h / 0 °C / Inert atmosphere

8.1: ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethoxy))cyclopentadienyl-chlorotitanium / tetrahydrofuran; diethyl ether / 2 h / -78 - 0 °C / Inert atmosphere

8.2: 5 h / -78 °C / Inert atmosphere

9.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With sodium hypochlorite; ammonium cerium (IV) nitrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; di-isopropyl azodicarboxylate; ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethoxy))cyclopentadienyl-chlorotitanium; asymmetric dihydroxylation-mix-α; methylmagnesium bromide; toluene-4-sulfonic acid; magnesium; methanesulfonyl chloride; hydroquinidein 1,4-phthalazinediyl diether; triethylamine; triphenylphosphine; mercury dichloride; potassium bromide; In tetrahydrofuran; diethyl ether; dichloromethane; water; toluene; acetonitrile; tert-butyl alcohol; 1.1: Mitsunobu reaction / 2.1: Sharpless dihydroxylation;
DOI:10.1021/ol203064r

Reference yield:

: 1351305-62-8
(3R)-3-hydroxy-3-methyl-7-[tris(propan-2-yl)silyl]hept-6-ynal

: 1351305-64-0
{4-[(4R,6S)-6-[(2R)-but-3-en-2-yl]-2-(4-methoxyphenyl)-4-methyl-1,3-dioxan-4-yl]but-1-yn-1-yl}tris(propan-2-yl)silane

Guidance literature:: Multi-step reaction with 2 steps

1.1: ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethoxy))cyclopentadienyl-chlorotitanium / tetrahydrofuran; diethyl ether / 2 h / -78 - 0 °C / Inert atmosphere

1.2: 5 h / -78 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / dichloromethane / 2 h / 20 °C / Inert atmosphere

With ((4S,5S)-2,2-dimethyl-1,3-dioxolane-4,5-bis(diphenylmethoxy))cyclopentadienyl-chlorotitanium; toluene-4-sulfonic acid; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1021/ol203064r