N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

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Chemical Name:N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide
CAS No.:1288342-19-7
Molecular Formula:C₂₀H₂₀ClF₃N₄O₂
Molecular Weight:440.853
Hs Code.:

Synonyms:N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

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Chemical Property of N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

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Technology Process of N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

There total 6 articles about N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1288342-18-6
N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-3-oxobutanamide

: 4637-24-5
N,N-dimethyl-formamide dimethyl acetal

: 1288342-19-7
N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

Guidance literature:: at 25 - 28 ℃;

Reference yield:

: 1062295-85-5,1027617-86-2
3-cyclopropyl-5-(trifluoromethyl)-1H-pyrazole

: 1288342-19-7
N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 90 °C / Inert atmosphere

1.2: 2 h / 90 °C

2.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 - 28 °C

3.1: ammonium chloride; iron / ethanol; water / 1 h / Reflux

4.1: xylene / 1.5 h / 145 °C

5.1: 25 - 28 °C

With N-chloro-succinimide; iron; potassium carbonate; ammonium chloride; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; xylene;

Reference yield:

: 30923-69-4
1‐cyclopropyl‐4,4,4‐trifluorobutane‐1,3‐dione

: 1288342-19-7
N-{4-[4-chloro-5-cyclopropyl-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-2-[(dimethylamino)methylene]-3-oxobutanamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrazine hydrate / ethanol / Reflux

2.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 90 °C / Inert atmosphere

2.2: 2 h / 90 °C

3.1: N-chloro-succinimide / N,N-dimethyl-formamide / 0 - 28 °C

4.1: ammonium chloride; iron / ethanol; water / 1 h / Reflux

5.1: xylene / 1.5 h / 145 °C

6.1: 25 - 28 °C

With N-chloro-succinimide; iron; potassium carbonate; ammonium chloride; hydrazine hydrate; In ethanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide; xylene;