(R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

Base Information

Chemical Name:(R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide
CAS No.:1277183-02-4
Molecular Formula:C₃₀H₄₁NO₃SSi
Molecular Weight:523.812
Hs Code.:

Synonyms:(R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

There total 5 articles about (R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 1277183-01-3
(+)-(S)-1-(3-methoxymethoxy-2-methylpropyl)diphenylsilane

: 221375-48-0
(N(E),R)-2-methyl-N-(2-phenylethylidene)-2-propanesulfinamide

: 1277183-02-4
(R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

Guidance literature:: (+)-(S)-1-(3-methoxymethoxy-2-methylpropyl)diphenylsilane; With lithium; In tetrahydrofuran; at 20 ℃; for 12h; Inert atmosphere;

(N(E),R)-2-methyl-N-(2-phenylethylidene)-2-propanesulfinamide; In tetrahydrofuran; at -78 - 20 ℃; Inert atmosphere;
DOI:10.1021/ol2002978

Reference yield:

: 1277183-00-2
fluoro(3-hydroxy-2-methylpropan-1-yl)diphenylsilane

: 1277183-02-4
(R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; lithium bromide / 1 h

2.1: lithium aluminium tetrahydride / diethyl ether / 0 °C / Reflux

3.1: lithium / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

3.2: -78 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; lithium; toluene-4-sulfonic acid; lithium bromide; In tetrahydrofuran; diethyl ether;
DOI:10.1021/ol2002978

Reference yield:

: 139017-02-0
(+)-4(S)-methyl-2,2-diphenyl-1-oxa-2-silacyclopentane

: 1277183-02-4
(R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen fluoride / ethanol; dichloromethane; water / 0 - 20 °C

2.1: toluene-4-sulfonic acid; lithium bromide / 1 h

3.1: lithium aluminium tetrahydride / diethyl ether / 0 °C / Reflux

4.1: lithium / tetrahydrofuran / 12 h / 20 °C / Inert atmosphere

4.2: -78 - 20 °C / Inert atmosphere

With lithium aluminium tetrahydride; hydrogen fluoride; lithium; toluene-4-sulfonic acid; lithium bromide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water;
DOI:10.1021/ol2002978