1277183-01-3

Upstream product

• 139017-02-0 (+)-4(S)-methyl-2,2-diphenyl-1-oxa-2-silacyclopentane 
• 1277183-00-2 fluoro(3-hydroxy-2-methylpropan-1-yl)diphenylsilane 
• 139016-78-7 1-(2-methyl-2-propenyl) diphenylsilyl ether 

Downstream Products

• 727726-32-1 [(2S)-2-methyl-3-hydroxy-1-propyl][(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilane 
• 727726-52-5 (2S)-3-[[(1R)-1-(benzoylamino)-2-phenylethyl]diphenylsilyl]-2-methylpropanoic acid 
• 1277183-02-4 (R)-N-{(1R)-1-[3-(methoxymethoxy)-2-(2S)-methylpropan-1-yl]diphenylsilyl-2-phenylethyl}(2-methylpropan-2-yl)sulfinamide 

Relevant academic research and scientific papers

Efficient, enantioselective assembly of silanediol protease inhibitors

A five-step assembly of silicon-protected dipeptide mimics from commercially available reagents is described. This methodology makes silanediol protease inhibitors readily available for the first time. The sequence features asymmetric hydrosilylation, a novel reduction of a silyl ether to a silyllithium reagent, and addition of this dianion to a sulfinimine, to produce the complete inhibitor skeleton with full control of stereochemistry. Oxidation of the primary alcohol to an acid completes the synthesis.