Chloramine-T

Base Information

• Chemical Name: Chloramine-T
• CAS No.: 127-65-1
• Deprecated CAS: 1576-40-5,72793-59-0,75532-46-6,8045-11-2,1071221-06-1,1172849-57-8,1976057-59-6,2143892-53-7,72793-59-0,75532-46-6,8045-11-2
• Molecular Formula: C7H7ClNNaO2S
• Molecular Weight: 229.663
• Hs Code.: 29242990
• European Community (EC) Number: 204-854-7,682-756-7
• ICSC Number: 0413
• UN Number: 1759
• UNII: 328AS34YM6
• DSSTox Substance ID: DTXSID6040321
• Nikkaji Number: J3.263H
• Wikipedia: Chloramine-T
• Wikidata: Q420695
• NCI Thesaurus Code: C152107
• Metabolomics Workbench ID: 143680
• ChEMBL ID: CHEMBL1697734
• Mol file: 127-65-1.mol

Synonyms:(N-chloro-p-toluenesulfonamide)sodium;chloramine T;chloramine-T;chloramine-T anhydrous;chloramine-T trihydrate;chloramine-T, 36Cl-labeled;Clorina;Euclorina;Hydroclonazone;sodium p-toluenesulfonchloramide

Chemical Property of Chloramine-T

Chemical Property:

• Appearance/Colour: white or yellow powder with a chlorine-like odour
• Vapor Pressure: 0Pa at 25℃
• Melting Point: 167-170 °C(lit.)
• Boiling Point: 314.3 °C at 760 mmHg
• PKA: 0.39[at 20 ℃]
• Flash Point: 143.9 °C
• PSA: 42.52000
• Density: 1.36g/cm3
• LogP: 3.29200
• Storage Temp.: 2-8°C
• Solubility.: H2O: >100 mg/mL
• Water Solubility.: 150g/L at 25℃
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 226.9783716
• Heavy Atom Count: 13
• Complexity: 231

Purity/Quality:

98% ^*data from raw suppliers

Sodium chloro(tosyl)amide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,C
• Hazard Codes: C,Xn
• Statements: 22-31-34-42
• Safety Statements: 22-26-36/37/39-45-7-1/2

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Uses -> Biocides/Disinfectants
• Canonical SMILES: CC1=CC=C(C=C1)S(=O)(=O)[N-]Cl.[Na+]
• Recent EU Clinical Trials: A phase III, multi-center, double-blind, randomized, vehicle controlled trial in a parallel-group design to evaluate the efficacy and safety of two formulations of Muxan containing 0.5 % or 1 % chloramine-T compared to vehicle in patients aged 12 years or older with acute herpes labialis
• Inhalation Risk: A harmful concentration of airborne particles can be reached quickly when dispersed, especially if powdered.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes, skin and respiratory tract.
• Effects of Long Term Exposure: Repeated or prolonged contact may cause skin sensitization. Repeated or prolonged inhalation may cause asthma.
• Uses: antiseptic, disinfestant, antiproliferative This disinfectant is for external use only, it can exterminate bacteria, viruses, fungi, spore. The action principle is that chlorine can sterilize slowly and lastingly, and also can dissolve necrotic tissue, chlorine come from hypochlorous acid which is produced by Chloramine-T solution. Apply to disinfect drinking water container,food,all kind of tableware, fruits and vegetables,and cleaning wound, mucous membrane. sterilizer, antiseptic, disinfectant, and chemical reagent in the medical and pharmaceutical fields.

Technology Process of Chloramine-T

There total 5 articles about Chloramine-T which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

toluene-4-sulfonamide (70-55-3) → chloroamine-T (127-65-1)

Guidance literature:

With trichloroisocyanuric acid; sodium hydroxide; at 20 ℃; for 1h;

DOI:10.1055/s-0029-1216889

Reference yield:

toluene-4-sulfonamide (70-55-3) → chloroamine-T (127-65-1)

Guidance literature:

With sodium hydroxide; water;

Reference yield:

N,N-dichloro-p-toluenesulfonamide (473-34-7) + toluene-4-sulfonamide (70-55-3) → chloroamine-T (127-65-1)

Guidance literature:

With indigo carmine; NaOAc-HOAc buffer; sodium perchlorate; In water; at 39.9 ℃; Equilibrium constant; var. pH (buffer);

DOI:10.1002/kin.550270706

upstream raw materials:

N,N-dichloro-p-toluenesulfonamide

toluene-4-sulfonamide

Downstream raw materials:

N,N'-bis-(toluene-4-sulfonyl)-ethanesulfinamidyne

N,N'-bis-(toluene-4-sulfonyl)-methanesulfinamidine

S,S-dipropyl-N-(toluene-4-sulfonyl)-sulfimide

3-hydroxy-2-oxopropionic acid

Refernces

• 1、 Chang, Sukbok,Jeon, Hyun Ji,Jung, Hoimin,Kim, Dongwook,Lee, Wongyu,Seo, Sangwon. "Controlled Relay Process to Access N-Centered Radicals for Catalyst-free Amidation of Aldehydes under Visible Light". supporting information. p. 495 - 508. Retrieved 2021/01/28.
• 2、 Gowda, B. Thimme,Damodara,Jyothi. "Kinetics and mechanism of oxidation of D-fructose and D-glucose by sodium salts of N-(chloro)-mono/di-substituted benzenesulfonamides in aqueous alkaline medium". . p. 572 - 582. Retrieved 2007/10/03.