8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

Base Information

Chemical Name:8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one
CAS No.:1374302-43-8
Molecular Formula:C₂₂H₁₈F₃N₃O
Molecular Weight:397.4
Hs Code.:

Synonyms:8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

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Chemical Property of 8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

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Technology Process of 8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

There total 8 articles about 8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1374302-44-9
5,5,5-trifluoro-2-((3-benzyl-5-phenylpyrazin-2-yl)amino)butanoic acid

: 1374302-43-8
8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

Guidance literature:: With pyridine; 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

: 371-26-6
ethyl 4,4,4-trifluorobutanoate

: 95-92-1
oxalic acid diethyl ester

: 1374302-43-8
8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

Guidance literature:: With sodium ethanolate; In ethanol;

Reference yield:

: 118311-18-5
5,5,5-trifluoro-2-oxopentanoic acid

: 70217-86-6
2-amino-3-benzyl-5-phenyl-pyrazine

: 1374302-43-8
8-benzyl-6-phenyl-2-(3,3,3-trifluoropropyl)imidazo[1,2-a]pyrazin-3(7H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h / 65 °C / Inert atmosphere

2: pyridine; 1,1'-carbonyldiimidazole / dichloromethane / 1 h / 20 °C

With pyridine; hydrogen; 1,1'-carbonyldiimidazole; palladium 10% on activated carbon; In ethanol; dichloromethane;