3-Benzyl-5-phenylpyrazin-2-amine

Base Information

• Chemical Name: 3-Benzyl-5-phenylpyrazin-2-amine
• CAS No.: 70217-86-6
• Molecular Formula: C17H15N3
• Molecular Weight: 261.326
• DSSTox Substance ID: DTXSID80436787
• Nikkaji Number: J1.834.837C
• Wikidata: Q82252099
• Mol file: 70217-86-6.mol

Synonyms:3-benzyl-5-phenylpyrazin-2-amine;70217-86-6;2-amino-3-benzyl-5-phenylpyrazine;SCHEMBL934707;SCHEMBL16982928;DTXSID80436787;TQP1057;HNGMHWCZZWCBON-UHFFFAOYSA-N;CS-0089193

Chemical Property of 3-Benzyl-5-phenylpyrazin-2-amine

Chemical Property:

• XLogP3: 3.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 261.126597491
• Heavy Atom Count: 20
• Complexity: 282

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)CC2=NC(=CN=C2N)C3=CC=CC=C3

Technology Process of 3-Benzyl-5-phenylpyrazin-2-amine

There total 19 articles about 3-Benzyl-5-phenylpyrazin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-amino-5-bromo-3-phenylmethylpyrazine (174680-55-8) + phenylboronic acid (98-80-6) → 2-amino-3-benzyl-5-phenyl-pyrazine (70217-86-6)

Guidance literature:

With [1,4-bis(diphenylphosphino)butane] palladium(ll) dichloride; cis-dichlorobis(benzonitrile)palladium(II); sodium carbonate; In ethanol; water; toluene; at 105 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.cclet.2016.02.011

Reference yield: 82.0%

5-amino-6-benzyl-2-O-trifluoromethanesulfonyloxypyrazine (853941-51-2) + phenylboronic acid (98-80-6) → 2-amino-3-benzyl-5-phenyl-pyrazine (70217-86-6)

Guidance literature:

With potassium phosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃;

DOI:10.3987/COM-05-10351

Reference yield: 77.0%

2-amino-3-benzyl-5-phenylpyrazine 1-oxide (196959-78-1) → 2-amino-3-benzyl-5-phenyl-pyrazine (70217-86-6)

Guidance literature:

With hydrogen; nickel; In ethanol; for 1.5h; Heating;

DOI:10.1039/a701156c

upstream raw materials:

2-amino-3-benzyl-5-phenylpyrazine 1-oxide

E-isonitrosoacetophenone

α-aminophenylpropiononitrile hydrochloride

2-N-(p-toluenesulfonyl)amide-3-benzyl-5-phenyl-pyrazine

Downstream raw materials:

N-(3-benzyl-5-phenyl-pyrazin-2-yl)-acetamide

8-benzyl-2-(4-hydroxyphenylmethyl)-6-phenyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one

2-benzyl-8-benzyl-6-(phenyl)imidazo[1,2-a]pyrazin-3(7H)-one

8-benzyl-2-methyl-6-phenylimidazo[1,2-a]pyrazin-3(7H)-one