(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

Base Information

Chemical Name:(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide
CAS No.:1363569-76-9
Molecular Formula:C₂₉H₃₁ClFN₅O₃
Molecular Weight:552.048
Hs Code.:

Synonyms:(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

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Chemical Property of (E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

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Technology Process of (E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

There total 8 articles about (E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-89-4
piperidine

: 1363569-80-5
(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-bromo-2-butenamide

: 1363569-76-9
(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

Guidance literature:: With caesium carbonate; In acetonitrile; at 40 ℃; for 12h;

Reference yield:

: 446-32-2
4-fluoroanthranilic acid

: 1363569-76-9
(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: acetic acid / 2-methoxy-ethanol / Reflux

2.1: nitric acid; sulfuric acid

3.1: thionyl chloride

4.1: isopropyl alcohol

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

5.2: 20 °C

6.1: acetic acid; iron / ethanol / 20 °C

7.1: triethylamine / dichloromethane / 12 h / 20 °C

8.1: caesium carbonate / acetonitrile / 12 h / 40 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; caesium carbonate; acetic acid; triethylamine; In ethanol; dichloromethane; 2-methoxy-ethanol; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; mineral oil;

Reference yield:

: 16499-57-3
7-fluoro-3H-quinazolin-4-one

: 1363569-76-9
(E)-N-[7-(7-oxabicyclo[2.2.1]heptan-2-yloxy)-4-(3-chloro-4-fluorophenylamino)quinazolin-6-yl]-4-(piperidin-1-yl)-2-butenamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: nitric acid; sulfuric acid

2.1: thionyl chloride

3.1: isopropyl alcohol

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / Cooling with ice

4.2: 20 °C

5.1: acetic acid; iron / ethanol / 20 °C

6.1: triethylamine / dichloromethane / 12 h / 20 °C

7.1: caesium carbonate / acetonitrile / 12 h / 40 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; caesium carbonate; acetic acid; triethylamine; In ethanol; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol; acetonitrile; mineral oil;