4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

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Chemical Name:4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide
CAS No.:683273-31-6
Molecular Formula:C₃₈H₄₁Cl₂N₃O₄Si
Molecular Weight:702.753
Hs Code.:

Synonyms:4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

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Chemical Property of 4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

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Technology Process of 4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

There total 1 articles about 4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.9%

: 177477-90-6
3-(N-Glycyl-N-methylamino)-1-(tert-butyldiphenyl-silyloxymethyl)-2,6-dichlorobenzene

: 194928-67-1
(E)-4-(N,N-dimethylcarbamoyl)cinnamic acid

: 683273-31-6
4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

Guidance literature:: With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; benzotriazol-1-ol; In N,N-dimethyl-formamide; for 3h;
DOI:10.1021/jm030159x

Reference yield: 98.4%

: 683273-31-6
4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

: 4-[(1E)-3-({2-[2,4-dichloro-3-(hydroxymethyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h;
DOI:10.1021/jm030159x

Reference yield:

: 683273-31-6
4-[(1E)-3-({2-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-2,4-dichloromethylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

: 683273-33-8
2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

Guidance literature:: Multi-step reaction with 2 steps

1: 98.4 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h

2: 94.2 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm030159x