2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

Base Information

Chemical Name:2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate
CAS No.:683273-33-8
Molecular Formula:C₂₃H₂₅Cl₂N₃O₆S
Molecular Weight:542.44
Hs Code.:

Synonyms:2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

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Chemical Property of 2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

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Technology Process of 2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

There total 5 articles about 2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.2%

: 124-63-0
methanesulfonyl chloride

: 4-[(1E)-3-({2-[2,4-dichloro-3-(hydroxymethyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

: 683273-33-8
2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.5h;
DOI:10.1021/jm030159x

Reference yield:

: 4-[(1E)-3-({2-[2,4-dichloro-3-(hydroxymethyl)methylanilino]-2-oxoethyl}amino)-3-oxo-1-propenyl]-N,N-dimethylbenzamide

: 683273-33-8
2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

Guidance literature:: With triethylamine; In dichloromethane; chloroform;

Reference yield:

: 177477-90-6
3-(N-Glycyl-N-methylamino)-1-(tert-butyldiphenyl-silyloxymethyl)-2,6-dichlorobenzene

: 683273-33-8
2,6-dichloro-3-({[((2E)-3-{4-[(dimethylamino)carbonyl]phenyl}-2-propenoyl)amino]acetyl}(methyl)amino)benzyl methanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 99.9 percent / 1-ethoxy-3-[3-(dimethylamino)propyl]carbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 3 h

2: 98.4 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h

3: 94.2 percent / Et₃N / CH₂Cl₂ / 0.5 h / 20 °C

With 1-(3-dimethylaminopropyl)-3-ethoxycarbodiimide hydrochloride; tetrabutyl ammonium fluoride; benzotriazol-1-ol; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm030159x