2-chloro-6-cyclohexylpyridine

Base Information

• Chemical Name: 2-chloro-6-cyclohexylpyridine
• CAS No.: 1184955-01-8
• Molecular Formula: C₁₁H₁₄ClN
• Molecular Weight: 195.692
• Mol file: 1184955-01-8.mol

Synonyms:2-chloro-6-cyclohexylpyridine

Chemical Property of 2-chloro-6-cyclohexylpyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 2-chloro-6-cyclohexylpyridine

There total 5 articles about 2-chloro-6-cyclohexylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

6-cyclohexylpyridin-2(1H)-one (1159814-04-6) → 2-chloro-6-cyclohexylpyridine (1184955-01-8)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 90 ℃; for 7h; Inert atmosphere;

DOI:10.1002/chem.200900563

Reference yield: 94.0%

2-tert-butoxy-6-cyclohexylpyridine (1184955-14-3) → 2-chloro-6-cyclohexylpyridine (1184955-01-8)

Guidance literature:

With trichlorophosphate; In N,N-dimethyl-formamide; at 90 ℃; Cooling with ice; Inert atmosphere;

DOI:10.1002/chem.200900563

Reference yield:

cyclohexane (110-82-7,25012-93-5) + N-methoxy-2-chloropyridinium methylsulfate (116570-79-7) → 2-chloro-6-cyclohexylpyridine (1184955-01-8) + 2-chloro-4-cyclohexylpyridine

Guidance literature:

With fac-tris(2-phenylpyridinato-N,C₂')iridium(III); sodium hydrogencarbonate; In acetonitrile; at 20 ℃; for 1h; Overall yield = 80 percent; Overall yield = 56 mg; regioselective reaction; Irradiation; Schlenk technique;

DOI:10.1021/acs.orglett.0c02863

upstream raw materials:

2-tert-butoxy-6-cyclohexylpyridine

6-cyclohexylpyridin-2(1H)-one

cyclohexane

N-methoxy-2-chloropyridinium methylsulfate

Downstream raw materials:

6-cyclohexyl-2-diphenylphosphinopyridine