2(1H)-Pyridinone, 6-cyclohexyl

Base Information

• Chemical Name: 2(1H)-Pyridinone, 6-cyclohexyl
• CAS No.: 1159814-04-6
• Molecular Formula: C₁₁H₁₅NO
• Molecular Weight: 177.246
• Mol file: 1159814-04-6.mol

Synonyms:

Chemical Property of 2(1H)-Pyridinone, 6-cyclohexyl

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

6-Cyclohexyl-1H-pyridin-2-one 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2(1H)-Pyridinone, 6-cyclohexyl

There total 5 articles about 2(1H)-Pyridinone, 6-cyclohexyl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

1-cyclohexyl-1,3-dioxo-propane (85606-56-0) + (2-amino-2-oxo-ethyl)triphenyl-phosphonium chloride (25361-54-0) → 1.3.5-Tris-(cyclohexylcarbonyl)-benzol (28811-77-0) + 2,6-dicyclohexylpyridine (292825-75-3) + 6-cyclohexylpyridin-2(1H)-one (1159814-04-6)

Guidance literature:

1-cyclohexyl-1,3-dioxo-propane; (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride; With triethylamine; In ethanol; at 20 - 80 ℃; for 14h;

With acetic acid; In ethanol; for 30h; Reflux;

DOI:10.1002/chem.200900563

Reference yield: 21.0%

1-cyclohexyl-1,3-dioxo-propane (85606-56-0) + (2-amino-2-oxo-ethyl)triphenyl-phosphonium chloride (25361-54-0) → 1.3.5-Tris-(cyclohexylcarbonyl)-benzol (28811-77-0) + 6-cyclohexylpyridin-2(1H)-one (1159814-04-6)

Guidance literature:

1-cyclohexyl-1,3-dioxo-propane; (2-amino-2-oxoethyl)(triphenyl)phosphonium chloride; With sodium hydroxide; In ethanol; at 80 ℃; for 4h;

With acetic acid; In ethanol; Reflux;

DOI:10.1002/chem.200900563

Reference yield:

2-benzyloxy-6-cyclohexyl-pyridine (676133-17-8) → 6-cyclohexylpyridin-2(1H)-one (1159814-04-6)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol;

DOI:10.1016/j.bmcl.2003.11.050

upstream raw materials:

2-benzyloxy-6-cyclohexyl-pyridine

2,6-Dibromopyridine

2-(benzyloxy)-6-bromopyridine

1-cyclohexyl-1,3-dioxo-propane

Refernces

• 1、 Thomson, Christopher G.,Beer, Margaret S.,Curtis, Neil R.,Diggle, Helen J.,Handford, Emma,Kulagowski, Janusz J.. "Thiazoles and thiopyridines: Novel series of high affinity h5HT 7 ligands". . p. 677 - 680. Retrieved 2007/10/03.