methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Base Information

Chemical Name:methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate
CAS No.:1618651-93-6
Molecular Formula:C₂₆H₃₄ClN₅O₆
Molecular Weight:548.039
Hs Code.:

Synonyms:methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Suppliers and Price of methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

There total 4 articles about methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5445-17-0
Methyl 2-bromopropionate

: 1618652-03-1
C₂₂H₂₈ClN₅O₄

: 1618651-93-6
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Guidance literature:: C₂₂H₂₈ClN₅O₄; With lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; N,N-dimethyl-formamide; at -78 ℃; for 0.0333333h; Inert atmosphere;

Methyl 2-bromopropionate; In tetrahydrofuran; ethylbenzene; N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1055/s-0033-1340499

Reference yield:

: 6336-42-1
2-amino-9-benzyl-6-chloro-9H-purine

: 1618651-93-6
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide; ethylbenzene / 0.03 h / -78 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With dmap; borane-THF; lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340499

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1618651-93-6
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dmap / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide; ethylbenzene / 0.03 h / -78 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

With dmap; borane-THF; lithium hexamethyldisilazane; In tetrahydrofuran; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340499