methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

Base Information

Chemical Name:methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate
CAS No.:1618652-01-9
Molecular Formula:C₂₆H₃₂ClN₅O₇
Molecular Weight:562.022
Hs Code.:

Synonyms:methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

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Chemical Property of methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

There total 5 articles about methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1618651-93-6
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-7,8-dihydro-9H-purin-7-yl}propanoate

: 1618652-01-9
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 0 ℃; for 0.333333h; Inert atmosphere;
DOI:10.1055/s-0033-1340499

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1618652-01-9
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide; ethylbenzene / 0.03 h / -78 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

With dmap; borane-THF; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340499

Reference yield:

: 6336-42-1
2-amino-9-benzyl-6-chloro-9H-purine

: 1618652-01-9
methyl 2-{9-benzyl-2-[bis(tert-butoxycarbonyl)amino]-8-oxo-7,8-dihydro-9H-purin-7-yl}propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere

2.1: borane-THF / tetrahydrofuran / 1 h / -78 - 0 °C / Inert atmosphere

3.1: lithium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide; ethylbenzene / 0.03 h / -78 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0.33 h / 0 °C / Inert atmosphere

With dmap; borane-THF; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; ethylbenzene; N,N-dimethyl-formamide;
DOI:10.1055/s-0033-1340499