2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

Base Information

Chemical Name:2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine
CAS No.:1617528-03-6
Molecular Formula:C₂₁H₂₀ClN₅O
Molecular Weight:393.876
Hs Code.:

Synonyms:2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

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Chemical Property of 2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

Chemical Property:

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Technology Process of 2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

There total 4 articles about 2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₁H₁₈ClN₅O

: 1617528-03-6
2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

Guidance literature:: With sodium cyanoborohydride; In ethanol; at 60 ℃; for 4h;
DOI:10.1016/j.ejmech.2014.05.059

Reference yield:

: 4-[(1,4-dihydro-4-oxo-2-pyrimidinyl)amino]benzonitrile

: 1617528-03-6
2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: trichlorophosphate / 0.5 h / Reflux

2: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C / Inert atmosphere

3: sodium hydride / N,N-dimethyl-formamide / 20 °C

4: sodium sulfate; acetic acid / ethanol / Reflux

5: sodium cyanoborohydride / ethanol / 4 h / 60 °C

With sodium hydride; sodium cyanoborohydride; acetic acid; sodium sulfate; trichlorophosphate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.05.059

Reference yield:

: 244768-32-9
4-[(4-chloro-2-pyrimidinyl)amino]benzonitrile

: 1617528-03-6
2-(4-cyanophenylamino)-4-(2-chlorophenyl-N-(2-hydroxypropyl)aminomethyl)pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / N,N-dimethyl-formamide / -20 - 20 °C / Inert atmosphere

2: sodium hydride / N,N-dimethyl-formamide / 20 °C

3: sodium sulfate; acetic acid / ethanol / Reflux

4: sodium cyanoborohydride / ethanol / 4 h / 60 °C

With sodium hydride; sodium cyanoborohydride; acetic acid; sodium sulfate; In ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2014.05.059