(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

Base Information

Chemical Name:(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene
CAS No.:133709-58-7
Molecular Formula:C₃₀H₄₀O₃Si
Molecular Weight:476.731
Hs Code.:

Synonyms:(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

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Chemical Property of (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

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Technology Process of (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

There total 13 articles about (1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 133709-57-6
(1R,2R,8R,8aR)-2-methyl-1-<3-<(1,1-dimethylethyl)diphenylsilyloxy>propyl>-1,2,3,4,6,7,8,8a-octahydronaphthalene-2,8-diol

: 133709-58-7
(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

Guidance literature:: With pyridine; pyridinium chlorochromate; In dichloromethane; for 2h; Ambient temperature;

Reference yield:

: 17553-86-5,19576-08-0,20007-98-1,17553-89-8
(R)-7a-methyl-2,3,7,7a-tetrahydro-6H-indene-1,5-dione

: 133709-58-7
(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

Guidance literature:: Multi-step reaction with 13 steps

2: 26.9 percent / pyridine / Ambient temperature

3: 50percent HF / acetonitrile / Ambient temperature

4: pyridine / Ambient temperature

5: NaI / acetone / Heating

6: acetonitrile / Heating

7: t-BuOK / tetrahydrofuran

8: Br₂ / CCl₄

9: m-CPBA, NaOAc, NaHCO₃ / CH₂Cl₂ / Heating

10: Zn, CH₃COOH / methanol / Ambient temperature

11: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

12: imidazole / dimethylformamide / 0.25 h / Ambient temperature

13: 75 percent / PCC, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; potassium tert-butylate; bromine; sodium acetate; sodium hydrogencarbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; sodium iodide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;

Reference yield:

: 131556-98-4,131557-15-8
(RS)-1-<(3aR,7S,7aR)-3a-methyl-3,6-dioxo-hexahydroindan-7-yl>-4-<(1,1-dimethylethyl)dimethylsilyloxy>butan-1-ol

: 133709-58-7
(1R,2R,8aR)-2-hydroxy-2-methyl-1-<3-<(1,1-dimethylethyl)-diphenylsilyloxy>propyl>-8-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalene

Guidance literature:: Multi-step reaction with 12 steps

1: 26.9 percent / pyridine / Ambient temperature

2: 50percent HF / acetonitrile / Ambient temperature

3: pyridine / Ambient temperature

4: NaI / acetone / Heating

5: acetonitrile / Heating

6: t-BuOK / tetrahydrofuran

7: Br₂ / CCl₄

8: m-CPBA, NaOAc, NaHCO₃ / CH₂Cl₂ / Heating

9: Zn, CH₃COOH / methanol / Ambient temperature

10: LiAlH₄ / tetrahydrofuran / 0.17 h / Heating

11: imidazole / dimethylformamide / 0.25 h / Ambient temperature

12: 75 percent / PCC, pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; 1H-imidazole; lithium aluminium tetrahydride; hydrogen fluoride; potassium tert-butylate; bromine; sodium acetate; sodium hydrogencarbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; pyridinium chlorochromate; sodium iodide; zinc; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone; acetonitrile;